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ProteomicsClinical application of multiple reaction monitoring-mass spectrometry to HER2 measurements as a potential diagnostic tool for breast cancer therapy
Although the determination of HER2 expression in breast cancer would be of critical importance in the clinical management related to the selection of the patients who are expected to benefit from trastuzumab therapy, the conventional techniques have inherent limitations that disqualify their use as ...
ORGANISM(S): Homo Sapiens 
2021-03-03 | PXD017691 | panorama
TranscriptomicsExpression profiling of E14 cells overexpressing Hk2/Pkm2
Purpose: In this study, we compared transcriptome profiling (RNA-seq) between normal mouse embryonic stem cell (E14) and Hexokinase2 (Hk2)/ Pyruvate Kinase M2 (Pkm2) overexpressed E14 cell. Result: Using an optimized data analysis workflow, we mapped over 4 billion sequence reads per sample to the m...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-65246 | biostudies-arrayexpress
GenomicsAlternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development
Mammalian development is an intricate process regulated by multiple gene isoforms and their epigenetic states, which are yet undefined. Using integrative massive parallel sequencing and bioinformatics approach, we built genome-wide inventory of transcript variants, their promoters and histone modifi...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-23525 | biostudies-arrayexpress
ProteomicsIntegrated NanoLC and UPLC-MS Platforms for Single Cell and Complex Mixture Analysis
Background: Multiple Reaction Monitoring (MRM) using triple quadrupole mass spectrometry (QqQ-MS) has become essential for multiplexed protein quantification. This study presents a comprehensive optimization of Agilent 6495C QqQ-MS equipped with both nano-electrospray ionization (nanoESI) and ultra-...
ORGANISM(S): Homo Sapiens 
PXD082365 | panorama
GenomicsChIP_seq
Ctbp2 regulates exit from pluripotency via silencing of embryonic stem cell active genes during differentiation. We mapped the genome-wide occupancy of Ctbp2 by ChIP-seq in mESC (E14).
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-2002 | biostudies-arrayexpress
TranscriptomicsE14RNA-seq
Ctbp2 regulates exit from pluripotency via silencing of embryonic stem cell active genes during differentiation. Gene expression profiles were analyzed for wild-type and Ctbp2-knockdown ESCs at both fferentiated(+LIF) and undifferentiated(-LIF) state.
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2030 | biostudies-arrayexpress
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