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MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
ProteomicsCo-immunoprecipitation and proteomic analysis of Major Histocompatibility Complex Class I-related (MR1) mutants
Identification of cellular proteins mediating presentation of bacterial antigens by the MHC I-related protein MR1. MR1 mutant proteins that differ in their capacity to present antigens from different sources were immunoprecipitated and their interacting proteins were compared to identify candidate p...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD063725 | Pride
Lcms Mr1 
UnknownRandomized, Open-Label Phase II Study Evaluating the Efficacy and Safety of Talimogene Laherparepvec in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced, Unresectable Melanoma.
Not available
S-EPMC6075852 | biostudies-literature
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (Mnase-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69474 | biostudies-arrayexpress
TranscriptomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (RNA-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69473 | biostudies-arrayexpress
UnknownImatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Not available
S-EPMC4878082 | biostudies-literature
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (ChIP-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69475 | biostudies-arrayexpress
UnknownAssignment of structural transitions during mechanical unwrapping of nucleosomes and their disassembly products.
Not available
S-EPMC9388122 | biostudies-literature
UnknownRNF144A-VRK2-G3BP1 axis regulates stress granule assembly.
Not available
S-EPMC11982375 | biostudies-literature
TranscriptomicsscRNAseq of immune cells of patients with chronic graft-versus-host disease
In this study, we investigated somatic mutations in T cells in patients with various hematological disorders. To analyze immune cell phenotypes with somatic mutations, we performed scRNA+TCRab sequencing from 9 patients with chronic GVHD and clonal expansions of CD4+ or CD8+ T cells based on T cell ...
ORGANISM(S): Homo sapiens 
2024-04-10 | E-MTAB-13419 | biostudies-arrayexpress
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