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ProteomicsApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
Recent developments in genome sequencing have expanded the knowledge of genetic factors associated with late-onset Alzheimer’s disease (AD). Among them, genetic variant e4 of the APOE gene (ApoE4) confers the greatest disease risk. Dysregulated glucose metabolism is an early pathological feature of ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-12 | PXD045298 | Pride
Mitophagy Lysosomal cholesterol accumulation Apoe4 Glucose metabolism Human astrocytes 
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