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MetabolomicsMapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC–MS
The metabolism of the parasite Trypanosoma brucei has been the focus of numerous studies since the 1940s. Recently it was shown, using metabolomics coupled with heavy-atom isotope labelled glucose, that the metabolism of the bloodstream form parasite is more complex than previously thought. The pres...
2019-06-24 | MTBLS624 | MetaboLights
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
ProteomicsHigh definition analysis of protein stability during cytomegalovirus infection informs on cellular restriction
Human cytomegalovirus (HCMV) is an important pathogen and a paradigm of viral immune evasion. Here, we describe a multiplexed approach to discover proteins with novel innate immune functions on the basis of their active proteasomal or lysosomal degradation during the early phase of HCMV infection. U...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2018-08-16 | PXD009945 | Pride
Innate immunity Immune evasion Lysosome Restriction factor Host-pathogen interaction Proteasome Protein degradation Tandem mass tag Quantitative proteomics Pulsed silac 
GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
ProteomicsSingle-Cell Proteomics in Marfan Syndrome Aortopathy Uncovers Cell-Specific Proteins
To better understand mechanisms of cell organization and function in the aortas of healthy and MFS patients, we performed single cell RNA sequencing (scRNA-seq) and label-free single-cell mass spectrometry35 in aortas isolated from healthy and MFS mice and human MFS aneurysm aortic tissue. We discov...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-14 | PXD078860 | Pride
Marfan syndrome Aortopathy Single-cell 
TranscriptomicsThe tinkerbell (tink) mutation identifies the dual-specificity MAPK phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a novel regulator of organ size in Arabidopsis.
Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants. In a screen for mutants with reduced organ size we have identified a mutation in the active site of the dual-specificity MAPK ph...
ORGANISM(S): Arabidopsis thaliana 
2015-07-30 | E-GEOD-66419 | biostudies-arrayexpress
ProteomicsMutagenesis of Key Phosphodiesterases in Toxoplasma gondii Demonstrates the Plasticity and Therapeutic Potential of Cyclic Nucleotide Signaling
Cyclic nucleotide signaling is pivotal to the asexual growth of T. gondii; however, little do we know about its counter-regulation in this parasite. We identified 18 phosphodiesterase (PDE1-18) enzymes, most of which form apicomplexan-specific clades and lack typical regulatory motifs found in mamma...
ORGANISM(S): Cellular Organisms 
2023-02-22 | PXD032173 | JPOST Repository
UnknownPilot studies for development of an HIV subtype panel for surveillance of global diversity.
Not available
S-EPMC3358106 | biostudies-literature
ProteomicsBulk Mass Spectrometry in Marfan Syndrome Aortopathy
Mass spectrometry was performed using aortic tissue from patients with Marfan syndrome or healthy controls and from a mouse model of Marfan syndrome (Fbn1 C1041G/+) or wild-type controls to validate single-cell proteomics.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-14 | PXD079005 | Pride
Human Marfan syndrome Thoracic aorta Lc-ms/ms 
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