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TranscriptomicsSingle-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. Using single nucleus RNA-sequencing (snRNAseq) of isolated nuclei from muscle fibers, we investigated nuclear heterogeneity and transcriptional dynamics in uninjured and regenerating muscle.
ORGANISM(S): Mus musculus 
2020-10-07 | E-MTAB-8623 | biostudies-arrayexpress
TranscriptomicsDiscovery of immediate YAP target genes with inducible form of YAP
Microarray analyses with cells/tissues overexpressing YAP have revealed many transcription targets of YAP (Dong et al, 2007; Zhao et al, 2008). However, as YAP induces transformation of non-cancerous cells, we thought many of known targets of YAP may be indirect consequence of transforming property ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-60579 | biostudies-arrayexpress
TranscriptomicsLocal translational program at the muscle-tendon junction endows domain identity in muscle syncytia - Riboseq
Skeletal muscle fibers are large multinucleated cells that form specialized subdomains such as the neuromuscular and myotendinous junctions (MTJ), the latter connecting muscle to tendon and transmitting contractile force. While transcriptional heterogeneity among myonuclei is established, the contri...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-16304 | biostudies-arrayexpress
TranscriptomicsLocal translational program at the muscle-tendon junction endows domain identity in muscle syncytia - RNAseq
Skeletal muscle fibers are large multinucleated cells that form specialized subdomains such as the neuromuscular and myotendinous junctions (MTJ), the latter connecting muscle to tendon and transmitting contractile force. While transcriptional heterogeneity among myonuclei is established, the contri...
ORGANISM(S): Mus musculus 
2026-09-30 | E-MTAB-16305 | biostudies-arrayexpress
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