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TranscriptomicsGlobal gene expression profiles of synoviocytes and macrophages in patients with rheumatoid arthritis and osteoarthritis
Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLS) and synovial macrophages (SM), are crucial for the progression of rheumatoid arthritis (RA). Particularly, FLS of RA patients (RA-FLS) exhibit invasive characteristics reminiscent of cancer cells, destroying cartilage and b...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-49604 | biostudies-arrayexpress
TranscriptomicsNFAT5 is a critical regulator of rheumatoid inflammation
NFAT5 is an osmoprotective transcription factor whose DNA binding domain shares structural homology with NFkappaB and other member of NFAT family, but its role in chronic inflammatory diseases remains unclear. The mRNA profiling of synoviocytes and endothelial cells transfected with NFAT5-targeted s...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22956 | biostudies-arrayexpress
TranscriptomicsGene expression profiling regulated by PDGF in pBSMCs
To explore global molecular changes in smooth muscle in response to PDGFR activation, primary human bladder smooth muscle cells were treated with 1 nM PDGF-BB (hereafter PDGF) for 0, 4 or 24 h. Total RNA were prepared, and analyzed using expression profiling, and subjected to bioinformatic and funct...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-52488 | biostudies-arrayexpress
TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
OtherIntegration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells.
Data from ProteomeXchange, PXD ID: PXD000624. File: WY_R103.mzml. Published as part of Cell Commun Signal. 2014 Aug 1;12(1):44 . From the Abstract: {{i}} ... Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the proliferation, migration and synthetic activities of smooth muscle cel...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002736 | GPMDB
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