Global gene expression profiles of synoviocytes and macrophages in patients with rheumatoid arthritis and osteoarthritis

ABSTRACT: Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLS) and synovial macrophages (SM), are crucial for the progression of rheumatoid arthritis (RA). Particularly, FLS of RA patients (RA-FLS) exhibit invasive characteristics reminiscent of cancer cells, destroying cartilage and bone, although it remains unresolved how RA-FLS exhibit invasive phenotype. RA-FLS and SM originate differently from mesenchymal and myeloid cells, respectively, but share many pathologic functions. However, the molecular signatures and biological networks representing the distinct and shared features of the two cell types are unknown. Presently, we performed global transcriptome profiling of FLS and SM obtained from RA and osteoarthritis patients. By comparing the transcriptomes, we identified d

ORGANISM(S): Homo sapiens

SUBMITTER: Sungyong You 

PROVIDER: E-GEOD-49604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress