Sort   by:  
 Page size 
UnknownHuman pluripotent stem-cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing.
Detailed understanding of the pathogenesis and development of effective therapies for pulmonary fibrosis (PF) have been hampered by lack of in vitro human models that recapitulate disease pathophysiology. In this study, we generated alveolar organoids (AOs) derived from human pluripotent stem cells ...
S-EPMC7961057 | biostudies-literature
UnknownAutographa californica multiple nucleopolyhedrovirus ORF11 is essential for budded-virus production and occlusion-derived-virus envelopment.

Unlabelled

ORF11 (ac11) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a highly conserved gene with unknown function. To determine the role of ac11 in the baculovirus life cycle, an ac11 knockout mutant of AcMNPV, Ac11KO, was constructed. Northern blot and 5' rapid ampli...
S-EPMC4301119 | biostudies-literature
UnknownAssociation between the body mass index and outcomes of patients resuscitated from out-of-hospital cardiac arrest: a prospective multicentre registry study.

Background

The effects of the body mass index (BMI) on outcomes of patients resuscitated from cardiac arrest are controversial. Therefore, the current study investigated the association between the BMI and the favourable neurologic outcomes and survival to discharge of patients resuscitated ...
S-EPMC7842019 | biostudies-literature
UnknownComparison between norepinephrine plus epinephrine and norepinephrine plus vasopressin after return of spontaneous circulation in patients with out-of-hospital cardiac arrest.
There is insufficient evidence regarding the use of second-line vasopressors following norepinephrine administration in the post-resuscitation management of patients with out-of-hospital cardiac arrest (OHCA). Therefore, this study aimed to investigate the survival outcomes between norepinephrine pl...
S-EPMC12008422 | biostudies-literature
UnknownFactors associated with shock-refractory prehospital cardiac arrest.
A significant number of out-of-hospital cardiac arrest (OHCA) patients experience refractory ventricular arrhythmias despite prompt defibrillation. These refractory arrhythmias are associated with poor clinical outcomes, underscoring the need to investigate improved management strategies. Therefore,...
S-EPMC12361564 | biostudies-literature
UnknownScaling and logic in the colour code on a superconducting quantum processor.
Quantum error correction1-4 is essential for bridging the gap between the error rates of physical devices and the extremely low error rates required for quantum algorithms. Recent error-correction demonstrations on superconducting processors5-8 have focused primarily on the sur...
S-EPMC12443611 | biostudies-literature
UnknownObservation of constructive interference at the edge of quantum ergodicity.
The dynamics of quantum many-body systems is characterized by quantum observables that are reconstructed from correlation functions at separate points in space and time1-3. In dynamics with fast entanglement generation, however, quantum observables generally become insensitive to the deta...
S-EPMC12545170 | biostudies-literature
UnknownA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulator...
S-EPMC9388392 | biostudies-literature
UnknownPolygenic prediction of body mass index and obesity through the life course and across ancestries.
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the ...
S-EPMC12443623 | biostudies-literature
Sort   by:  
 Page size