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TranscriptomicsGene expression profiling of colorectal cancers to understand molecular changes and clinicopathological features
Gene expression was analyzed in terms of canonical molecular changes and clinicopathological features to elucidate alternative or subordinate pathways during colorectal tumorigenesis and tumor growth. Eighty-four sporadic colorectal cancer patients, standardized by tumor location, were consecutively...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-10982 | biostudies-arrayexpress
TranscriptomicsGene expression profiling study by RNA-seq in colorectal cancer
The objective of this study is to identify a prognostic signature in colorectal cancer (CRC) patients with diverse progression and heterogeneity of CRCs. We generated RNA-seq data of 54 samples (normal colon, primary CRC, and liver metastasis) from 18 CRC patients and, from the RNA-seq data, identif...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-50760 | biostudies-arrayexpress
GenomicsGenome-wide binding of TEAD4 in gastric cancer cell lines MKN28 and SNU216
To access target binding sites of TEAD4 in gastric cancer, TEAD4 binding was investigated using MKN28 and SNU216 cell lines by ChIP-seq. MKN28 and SNU216 cell lines were cross-linked with formaldehyde, fractionated by sonication and immunoprecipitated by TEAD4 antibody. Immunoprecipitated DNA was pr...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-44416 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression analysis by TEAD4 knockdown in a gastric cancer cell line SNU216
To access oncogenic roles of TEAD4 in gastric cancer, TEAD4-regulated genes were investigated using a SNU216 cell line in which TEAD4 expression was knockdown by shRNA. To compare control to TEAD4 knockdown cell, total RNA was extracted from two cell lines generated by non-silencing shRNA control an...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-44383 | biostudies-arrayexpress
GenomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
We performed H3K27ac ChIP-seq data in seven gastric cancer cell lines to investigate the functional significance of epigenetic changes at distal regulatory regions H3K27ac ChIP-seq profiling of gastric cancer cell lines were generated by deep sequencing, in each seven samples, using Illumina GAIIx a...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-75595 | biostudies-arrayexpress
GenomicsDynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cell (hMeDIP-Seq and MBD-Seq)
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge about the genome-wide distribution of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) during cellular differentiation remains limited. Using in vitro model system of gra...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-38214 | biostudies-arrayexpress
TranscriptomicsPromoter methylation data from genomic DNA in patient with rectal cancer
The identification of surrogate methylation markers that can predict responses to preoperative chemoradiotherapy (CRT) in rectal cancer patients. Genome-wide association studies in clinical populations are theoretically capable of identifying markers that are capable of tumor regression after CRT. W...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-39958 | biostudies-arrayexpress
TranscriptomicsDynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cells (Methylation BeadChip)
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge about the genome-wide distribution of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) during cellular differentiation remains limited. Using in vitro model system of gra...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-38216 | biostudies-arrayexpress
TranscriptomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines. mRNA sequencing profiles of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were genera...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-46597 | biostudies-arrayexpress
GenomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines MBD sequencing of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were generated by deep...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-46595 | biostudies-arrayexpress
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