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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
GenomicsDynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cell (hMeDIP-Seq and MBD-Seq)
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge about the genome-wide distribution of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) during cellular differentiation remains limited. Using in vitro model system of gra...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-38214 | biostudies-arrayexpress
TranscriptomicsDynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cells (Methylation BeadChip)
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge about the genome-wide distribution of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) during cellular differentiation remains limited. Using in vitro model system of gra...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-38216 | biostudies-arrayexpress
GenomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
We performed H3K27ac ChIP-seq data in seven gastric cancer cell lines to investigate the functional significance of epigenetic changes at distal regulatory regions H3K27ac ChIP-seq profiling of gastric cancer cell lines were generated by deep sequencing, in each seven samples, using Illumina GAIIx a...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-75595 | biostudies-arrayexpress
TranscriptomicsAdaptive evolution of Corynebacterium glutamicum resistant to oxidative stress and its global gene expression profiling
Corynebacterium glutamicum was adapted in a chemostat for 1,900 h with gradually increasing H2O2 stress to understand the oxidative stress response of an industrial host. After 411 generations of adaptation, C. glutamicum developed the ability to grow under stress of 10 mM H2O2, whereas the wild-typ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2013-01-06 | E-GEOD-41232 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing for cancer stem cell properties in MCF-7 cells with knocked down CD24
CD24 is the one of cell surface protein that anchored via glycosyl phosphatidylinositol that links to cell surface and modulates growth and differentiation signal many of cell types. A small population of cells, namely M-bM-^@M-^XCancer Stem Cells (CSCs)M-bM-^@M-^Y, charges highly aggressive and met...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-61917 | biostudies-arrayexpress
TranscriptomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines. mRNA sequencing profiles of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were genera...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-46597 | biostudies-arrayexpress
GenomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines MBD sequencing of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were generated by deep...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-46595 | biostudies-arrayexpress
TranscriptomicsGene expression in S1 panicles of Ubi1:AtJMT transgenic plants and drought-treated nontransgenic rice plants
To identify genes that are regulated by MeJA and drought, global expression profilings were performed on panicles from Ubi1:AtJMT, drought-treated NT, and untreated NT plants. The underlying assumption of this approach was that high levels of MeJA produced either by overexpression of AtJMT in the tr...
ORGANISM(S): Oryza sativa 
2009-07-09 | E-GEOD-14508 | biostudies-arrayexpress
TranscriptomicsDynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-38217 | biostudies-arrayexpress
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