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GenomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
We performed H3K27ac ChIP-seq data in seven gastric cancer cell lines to investigate the functional significance of epigenetic changes at distal regulatory regions H3K27ac ChIP-seq profiling of gastric cancer cell lines were generated by deep sequencing, in each seven samples, using Illumina GAIIx a...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-75595 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing for cancer stem cell properties in MCF-7 cells with knocked down CD24
CD24 is the one of cell surface protein that anchored via glycosyl phosphatidylinositol that links to cell surface and modulates growth and differentiation signal many of cell types. A small population of cells, namely M-bM-^@M-^XCancer Stem Cells (CSCs)M-bM-^@M-^Y, charges highly aggressive and met...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-61917 | biostudies-arrayexpress
TranscriptomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines. mRNA sequencing profiles of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were genera...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-46597 | biostudies-arrayexpress
GenomicsIntegrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer
To understand epigenetic changes in the distal regulatory as well as proximal regions, we performed RNA-seq, MBD-seq, and H3K27ac ChIP-seq on gastric tissues and cell lines MBD sequencing of normal tissue (n), purified gastric cancer (sc), and cultured gastric cancer cell (dc) were generated by deep...
ORGANISM(S): Homo sapiens 
2016-03-28 | E-GEOD-46595 | biostudies-arrayexpress
MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
TranscriptomicsRNAseq analyses of pathogenic Burkholderia glumae under in vitro and in vivo conditions
We analyzed B. glumae transcriptome from infected rice tissue using an RNAseq technique. To identify unique expression of B. glumae genes within rice tissues, we compared in vivo transcriptome data of B. glumae to in vitro data. To accomplish this, we analyzed differentially expressed genes (DEGs) a...
ORGANISM(S): Burkholderia glumae BGR1 
2014-08-21 | E-GEOD-56958 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans
Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing rev...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-31 | E-GEOD-21192 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of quorum sensing-dependent genes in Burkholderia glumae BGR1
Burkholderia glumae causes rice grain rot and sheath rot by producing toxoflavin, whose expression is regulated by quorum sensing (QS). The QS systems of the bacterium rely on N-octanoyl homoserine lactone, synthesized by TofI and its cognate receptor TofR, to activate toxoflavin biosynthesis genes ...
ORGANISM(S): Burkholderia glumae 
2012-03-14 | E-GEOD-36485 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of CKD urine samples
Urinary proteomics studies have primarily focused on identifying markers of chronic kidney disease (CKD) progression. Here, we aimed to specify CKD-related injury markers through proteomics analysis in urine of patients with CKD. Label-free quantitative proteomics analysis based on liquid chromatogr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-15 | MSV000087635 | MassIVE
MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
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