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MetabolomicsThe Leiden Longevity Study: Identification of biomarkers of the rate of ageing
The aim of the study is to identify genetic mechanisms of longevity and to characterize their interaction with the environment. Using the results the future health of people without familial longevity can be improved in old age. Long-lived siblings of European descent were recruited together with th...
2019-07-11 | MTBLS974 | MetaboLights
TranscriptomicsA new dataset of spermatogenic vs oogenic transcriptomes in the nematode C. elegans
The nematode Caenorhabditis elegans is an important model for studies of germ cell biology, including specification as sperm or oocyte, the meiotic cell cycle and gamete differentiation. Fundamental to those studies is a genome-level knowledge of the germline transcriptome. Here we use RNA-Seq to ...
ORGANISM(S): Caenorhabditis elegans 
2014-07-29 | E-GEOD-57109 | biostudies-arrayexpress
GenomicsAn Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (ChIP-Seq)
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during post-natal spermatogenesis and account ...
ORGANISM(S): Mus musculus 
2013-03-26 | E-GEOD-44588 | biostudies-arrayexpress
TranscriptomicsComparative Validation of the D. melanogaster Encyclopedia of DNA Elements Transcript Models
The model organism Encyclopedia of DNA Elements project (modENCODE) has produced a comprehensive annotation of D. melanogaster transcript models based on an enormous amount of high-throughput experimental data. However, some transcribed elements may not be functional, and technical artifacts may lea...
ORGANISM(S): Drosophila ficusphila 
2013-02-25 | E-GEOD-44612 | biostudies-arrayexpress
UnknownCell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.
Not available
S-EPMC4718729 | biostudies-literature
TranscriptomicsA nuclear Argonaute promotes germline immortality and epigenetic inheritance across generations
dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...
ORGANISM(S): Caenorhabditis elegans 
2012-07-30 | E-GEOD-38041 | biostudies-arrayexpress
UnknownFunctional significance of PUF partnerships in C. elegans germline stem cells.
Not available
S-EPMC9949348 | biostudies-literature
UnknownMultiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.
Not available
S-EPMC6934292 | biostudies-literature
GenomicsAn Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Gallus gallus 
2013-03-26 | E-GEOD-44690 | biostudies-arrayexpress
TranscriptomicsQUORUM SENSING IN A METHANE-OXIDIZING BACTERIUM
Aerobic methanotrophic bacteria use methane as their sole source of carbon and energy and serve as a major sink for the potent greenhouse gas methane in freshwater ecosystems. Despite this important environmental role, little is known about the molecular details of how these organisms interact in th...
ORGANISM(S): Methylobacter tundripaludum 21/22 
2016-08-16 | E-GEOD-85617 | biostudies-arrayexpress
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