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TranscriptomicsMouse primary megakaryocytes, wild type & NF-E2p45-deficient
To identify p45 target genes, we conducted gene expression profiling with p45-null megakaryocytes cultured from E14.5 fetal liver. Many genes encoding membrane proteins and enzymes related to platelet function, including Txas, Glycoprotein 6 (Gp6) and Selectin P (Selp), were repressed in the absence...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-15581 | biostudies-arrayexpress
TranscriptomicsExpression data of HUVEC cells after TNF-alpha treatment
Tumor necrosis factor a (TNF-aplha) is a potent cytokine that orchestrates the inflammatory response by sequentially activating the expression of many genes in cultured human umbilical vein cells (HUVECs). We apply samples collected every 7.5 min to arrays and monitor the growth of several long tran...
ORGANISM(S): Homo sapiens 
2007-09-19 | E-GEOD-9036 | biostudies-arrayexpress
ProteomicsProteomic analysis using BRG1-phosphorylation mutants
Proteins extracted from stable clones expressing wild-type, phosphorylation-mimic (brg1-S1452D), or non-phosphorylatable BRG1 (brg1-S1452A) were trypsin-digested and analyzed by Q Exactive Quadrupole-Orbitrap LC-MS.
ORGANISM(S): Homo Sapiens (human) 
2021-11-24 | PXD022681 | JPOST Repository
ProteomicsMS analysis of phosphopeptides enriched from BRG1-phospho mutants
Phosphopeptides enriched from stable clones expressing wild-type, phosphorylation-mimic (brg1-S1452D), or non-phosphorylatable BRG1 (brg1-S1452A) were analyzed by Q Exactive Quadrupole-Orbitrap LC-MS.
ORGANISM(S): Homo Sapiens (human) 
2021-11-24 | PXD022680 | JPOST Repository
TranscriptomicsAnalysis of small RNAs in piRNA pathway mutant mouse testes
Piwi-interacting RNAs are 25-32 nt small RNAs bound to Piwi proteins. To know the steps where factors involved in the piRNA biogenesis (MILI, MIWI2, ZUC (MitoPLD), MVH) work, we sequenced small RNAs from mutant mouse testes and analyzed piRNAs. Examination of small RNAs in testes of mutant mouse
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20327 | biostudies-arrayexpress
TranscriptomicsNew anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.
Background: EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2-7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is likely confined to various types of cancer, particularly glioblastomas. Althou...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-76959 | biostudies-arrayexpress
ProteomicsProteomics data of mouse skeletal muscles (microgravity exposure)
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as ...
ORGANISM(S): Mus Musculus (mouse) 
2021-07-30 | PXD021550 | JPOST Repository
ProteomicsProteomics data of mouse skeletal muscles (hypergravity exposure)
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as ...
ORGANISM(S): Mus Musculus (mouse) 
2020-02-20 | PXD017240 | JPOST Repository
ProteomicsCoRest’s acetylation acts as a temporal gate for activity-dependent transcription, limiting behavioral flexibility in Drosophila
In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2020-12-07 | PXD021294 | JPOST Repository
ProteomicsInteractome analysis for Kdm4B
In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed ...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2023-08-12 | PXD039097 | JPOST Repository
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