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UnknownCooperative Function of Atg8- and TORC1-Mediated Activities in Yeast.
Not available
S-EPMC12511908 | biostudies-literature
ProteomicsUse of data-independent acquisition mass spectrometry to identify an objective serum indicator of the need for osteoporotic therapeutic intervention
Osteoporosis is characterized by weakened bone microstructure and loss of bone mass. Current diagnostic criteria for osteoporosis are based on the T-score, which is a measure of bone mineral density. However, osteoporotic fragility fractures can occur regardless of the T-score, underscoring the need...
ORGANISM(S): Homo Sapiens (human) 
PXD041546 | JPOST Repository
UnknownLiver function effects of SGLT2 inhibitor and GLP-1 receptor agonist combination treatment in patients with type 2 diabetes (post hoc analysis of RECAP study).
Not available
S-EPMC12209503 | biostudies-literature
TranscriptomicsDevelopment of gene expression signatures for ANP in HUVEC
Analysis of HUVEC treated with ANP. ANP is a cardiac hormone, binding to the guanylate cyclase-A (GC-A) receptor with a major role in cardiovascular homeostatic mechanisms. Results provide insight into the molecular mechanisms of ANP in vascular endothelial cell. ANP induced gene expression in HUVEC...
ORGANISM(S): Homo sapiens 
2014-04-23 | E-GEOD-56976 | biostudies-arrayexpress
ProteomicsComprehensive human serum spectral library
For a comprehensive analysis of the human serum proteome, we constructed a spectral library for DIA-MS. Our spectral library contained information on 20,303 peptides derived from 1,597 human serum proteins. We believe that the constructed spectral library will be useful for proteomic analysis of hum...
ORGANISM(S): Homo Sapiens (human) 
PXD041558 | JPOST Repository
ProteomicsChanges in the astronaut serum proteome during prolonged spaceflight
The molecular mechanisms associated with spaceflight-induced biological adaptations that may affect many healthy tissue functions remain poorly understood. In this study, we analyzed temporal changes in the serum proteome of six astronauts during prolonged spaceflight missions using quantitative com...
ORGANISM(S): Homo Sapiens (human) 
2024-01-22 | PXD044609 | JPOST Repository
GenomicsGenome-wide maps of MEF2C and H3K27ac localization in HUVECs
MEF2C is one of the substantially expressed transcriptional factors in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for MEF2C, and performed ChIP-seq to identify MEF2C binding site in whole genome manner. H3K27Ac binding sites were also detec...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32644 | biostudies-arrayexpress
ProteomicsThe original mouse bone spectral library for the DIA-MS
We successfully constructed a customized spectral library containing information on 1,394 proteins for DIA-MS; the library can be used for comprehensive identification and quantification of proteins expressed in the mouse bones.
ORGANISM(S): Mus Musculus (mouse) 
PXD041731 | JPOST Repository
ProteomicsIdentification of gravity-responsive proteins in the femur of spaceflight mice using a quantitative proteomic approach
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Utilizing proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as...
ORGANISM(S): Mus Musculus (mouse) 
PXD041738 | JPOST Repository
ProteomicsPlasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of muscul...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-01 | PXD041806 | JPOST Repository
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