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TranscriptomicsThe kinase TNIK is an essential activator of Wnt target genes
Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/ß-catenin activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/ß-catenin transcriptional progra...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17623 | biostudies-arrayexpress
GenomicsA mouse model for assessing mTOR kinase-independent role and off-target effect of mTOR kinase inhibitors [II]
A mouse model for assessing mTOR kinase-independent role and off-target effect of mTOR kinase inhibitors [II]
PRJNA722522 | ENA
GenomicsA mouse model for assessing mTOR kinase-independent role and off-target effect of mTOR kinase inhibitors [I]
A mouse model for assessing mTOR kinase-independent role and off-target effect of mTOR kinase inhibitors [I]
PRJNA722519 | ENA
GenomicsA mouse model for assessing mTOR kinase-independent role and off-target effect of mTOR kinase inhibitors [III]
A mouse model for assessing mTOR kinase-independent role and off-target effect of mTOR kinase inhibitors [III]
PRJNA984322 | ENA
ProteomicsChemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activation
Identification of covalently bound protein targets of probe WEL028 in wild-type or mutant HL-60 cells.
ORGANISM(S): Homo sapiens (Human) 
2020-05-25 | PXD018270 | Pride
Target validation Chemical genetics Inhibitor Target engagement Chemical biology Kinase Probe 
GenomicsTarget BUB1 kinase as a therapeutic strategy for inhibiting STAT3 signal pathway in Bladder cancer
Target BUB1 kinase as a therapeutic strategy for inhibiting STAT3 signal pathway in Bladder cancer
PRJNA534083 | ENA
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
TranscriptomicsIdentification of a target gene and activating stimulus for the YpdA/YpdB histidine kinase/response regulator system in Escherichia coli
To identify YpdB-regulated genes, the transcriptome profiles of E. coli cells overproducing either the response regulator (RR) YpdB or the RR YehS (control) were comparatively analyzed. The expression level of 15 genes varied more than 1.9-fold.
ORGANISM(S): Escherichia coli 
2012-10-30 | E-MTAB-1347 | biostudies-arrayexpress
ProteomicsSite-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags
Protein kinases are prime targets for drug development due to their involvement in various cancers. However, selective inhibition of kinases, while avoiding off-target effects remains a significant challenge for the development of protein kinase inhibitors. Activity-based protein profiling (ABPP), i...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058749 | Pride
Chemical proteomics  activity-based protein profiling  site-specific  protein kinase inhibitor profiling  ephrin receptor inhibitor  nvp-bhg712 
TranscriptomicsIdentification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA
This SuperSeries is composed of the following subset Series: GSE21719: Identification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA (miRNA study) GSE21832: Identification of the receptor tyrosine kinase AXL in triple negative br...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21834 | biostudies-arrayexpress
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