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UnknownSomatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure.
Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the underlying factors that generate somatic mutations is therefore crucial for developing novel therapeutic strategies. To understand the interpla...
S-EPMC8350746 | biostudies-literature
UnknownDevelopment of a Quality Indicator Set for the Optimal Acute Management of Moderate to Severe Traumatic Brain Injury in the Australian Context.

Background

The aim of this study was to develop a consensus-based set of indicators of high-quality acute moderate to severe traumatic brain injury (msTBI) clinical management that can be used to measure structure, process, and outcome factors that are likely to influence patient outcomes. T...
S-EPMC11950108 | biostudies-literature
Genomics3a29872b-a736-415c-b42b-d2ee95d79c54 - samples
WGS with linked reads of pediatric glioblastoma. For each patient, blood and tumor tissue were sequenced. For two patients, we also provide sequencing data for the blood of their parents.
EGAD00001005212 | EGA
GenomicsWhole genome sequencing with linked reads of pediatric glioblastoma samples
Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand mechanisms of tumor evolution in this cancer, we performed whole genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were...
EGAS00001003432 | EGA
GenomicsCharbonneau Cancer Institute DAC
Data Access Committee EGAC00001001280
EGAC00001001280 | EGA
UnknownTwo Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.

Background

Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear.

Methods

We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the HVTN 704/HPTN 085 trial and at-risk ...
S-EPMC8189692 | biostudies-literature
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
GenomicsBC
WTCCC1 project Breast cancer (BC) samples
EGAD00000000013 | EGA
GenomicsMS
WTCCC1 project Multiple Sclerosis (MS) samples
EGAD00000000012 | EGA
GenomicsWTCCC2 Ankylosing spondylitis cases - individual
WTCCC1 project Ankylosing Spondylitis (AS) samples
EGAD00000000010 | EGA
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