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ProteomicsTMT-based proteomics analysis of optic nerve lysates from oligodendrocyte-specific Kir4.1 knockout mice
To study the role oligodendroglial Kir4.1 in regulating axonal energy metabolism, oligodendrocyte-specific Kir4.1 knockout mice and their littermate controls were used; optic nerve lysates were prepared for subsequent TMT-based proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-30 | PXD046207 | Pride
Lc-msms Mouse Tmt proteomics Optic nerve Oligodendrocytes Kir4.1 knockout 
GenomicsKir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe
Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe
PRJNA1040193 | ENA
TranscriptomicsKir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe
Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO2/H+, however, it is not clear how these cells detect changes in CO2/H+. Considering Kir4.1/5.1 channels are CO2/H+-sensitive and important for several astrocyte-dependent processes, we consider Kir4.1/5.1 a leading ...
ORGANISM(S): Mus musculus 
2023-12-29 | GSE247704 | GEO
GenomicsSpinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain
Spinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain
PRJNA860965 | ENA
TranscriptomicsSpinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain
Previous studies have suggested that astrocyte activation in the spinal dorsal horn may play an important role in the development of chronic neuropathic pain; but the mechanisms involved in astrocyte activation and their modulatory effects remain unknown. The inward rectifying potassium channel prot...
ORGANISM(S): Mus musculus 
2022-07-24 | GSE208766 | GEO
UnknownFunctional expression of Kir4.1 channels in spinal cord astrocytes.
Not available
S-EPMC2553202 | biostudies-literature
UnknownKir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.
Not available
S-EPMC6230743 | biostudies-literature
UnknownRenal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.
Not available
S-EPMC7269345 | biostudies-literature
UnknownOligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
Not available
S-EPMC6167053 | biostudies-literature
UnknownKir4.1/Kir5.1 Activity Is Essential for Dietary Sodium Intake-Induced Modulation of Na-Cl Cotransporter.
Not available
S-EPMC6362624 | biostudies-literature
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