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ProteomicsReduced proteasome activity in the aging brainresults in ribosome stoichiometry loss and aggregation
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We ...
ORGANISM(S): Mus musculus (Mouse) Nothobranchius furzeri 
2020-08-17 | PXD018399 | Pride
Proteasome activity Aging brain Ribosome stoichiometry Aggregation 
ProteomicsSpecies comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
Mammals display wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the liver of long-lived naked mole-rats (NMRs) and the phylogenetically closely r...
ORGANISM(S): Homo sapiens (Human) Heterocephalus glaber Cavia porcellus (Guinea pig) 
2018-06-21 | PXD008720 | Pride
Naked mole-rat Liver Longevity Human aging 
ProteomicsRad21-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation
MTD project_description Inflammation and decreased stem cell function characterize organism aging, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells exhibit increased ground-stage NF-κB activity, which enhan...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-28 | PXD011537 | Pride
Hematopoietic stems cells Inflammation Aging 
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