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TranscriptomicsImpaired DNA damage metabolism promotes autoimmunity in TREX1 deficiencyÂ
Constitutive low level DNA damage is linked to innate immune activation. Hierarchical clustering of over 9000 transcripts revealed remarkably similar profiles in a patient with lupus erythematosus and a patient with AGS with up-regulation of genes involved in DNA damage signaling, p53-inducible gene...
ORGANISM(S): Homo sapiens 
2016-05-30 | E-GEOD-59233 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of hiPSC derived alveolar-like lung organoids upon H3N2 infection
hiPSC from 2 different donors were differentiated into alveolar-like organoids (iPSC-aLOs) as previously described (DOI: 10.1038/s41596-019-0220-0). iPSC-aLOs were either kept in \"dome\" culture embedded in extracellular matrix or inverted in apical-out conformation to allow influenza H3N2 infectio...
ORGANISM(S): Homo sapiens 
2025-11-27 | E-MTAB-15980 | biostudies-arrayexpress
TranscriptomicsCharacterization of perivascular MSC from the adult human brain
Brain perivascular cells have been recently identified as new mesodermal cell type of the human brain. These cells reside in the perivascular niche and were shown to have mesodermal and – to a lesser extend – tissue-specific differentiation potential. Mesenchymal stem cells (MSCs) are widely dis...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-62505 | biostudies-arrayexpress
ProteomicsRNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
RIG-I like helicases (RLHs) and cGAS are crucial cytosolic sensors of viral RNA and DNA, respectively, and induce type I IFNs via TBK1/IKKε. hnRNPM was described to possess antimicrobial activities. Here, we show that hnRNPM promotes IRF3 phosphorylation and type I IFN induction downstream of cGAS a...
ORGANISM(S): Homo sapiens (Human) 
2024-11-11 | PXD028160 | Pride
Ap-ms Lc-ms/ms 
TranscriptomicsHuman adult white matter progenitor cells are multipotent neuroprogenitors identical to adult hippocampal progenitors
Adult neural progenitor cells (aNPCs) are a potential autologous cell source for cell replacement in neurologic diseases such as Parkinson’s disease or stroke or for cell-based gene therapy for neurometabolic diseases. Easy accessibility, long-term expandability and detailed characterization of ...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-47921 | biostudies-arrayexpress
UnknownRNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
Not available
S-SCDT-10_1038-S44318-024-00331-X | biostudies-other
TranscriptomicsDefective removal of ribonucleotides from DNA promotes systemic autoimmunity
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signalin...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63755 | biostudies-arrayexpress
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