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ProteomicsWhole proteome and Secretome analysis of Staphylococcus aureus ClpXP mutant strains
Staphylococcus aureus represents an opportunistic pathogen which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system in controlling pathogenesis. While detailed transcri...
ORGANISM(S): Bacteria Staphylococcus aureus 
2021-03-12 | PXD018932 | Pride
Proteomics Staphylococcus aureus Whole proteome analysis Lc-ms/ms 
ProteomicsThe cytotoxic natural product vioprolide A targets nucleolar protein 14 essential for ribosome biogenesis
The cytotoxic and antifungal peptolides vioprolide A-D were discovered in 1996, however their mode-of-action has so far been unsolved. Anti-cancer effect of the most potent cytotoxic derivative vioprolide A (VioA) were evaluated, showing a prominent potency against human acute lymphoblastic leukemia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD015196 | Pride
Natural product Afbpp Lc-ms Target identification Thermal proteome profiling Co-ip 
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