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TranscriptomicsTranscription profiling of human lamina cribrosa cells in vitro treated with mechanical strain
The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the l...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human GFAP-negative lamina cribrosa cells TGF-beta regulated gene transcription and protein expression
Primary open angle glaucoma (POAG) is a progressive optic neuropathy, which is a major cause of worldwide visual impairment and blindness. Pathological hallmarks of the glaucomatous optic nerve head include retinal ganglion cell axon loss and extracellular matrix (ECM) remodeling of the lamina cribr...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2705 | biostudies-arrayexpress
MetabolomicsCharacterisation of monophasic solvent-based tissue extractions for detection of polar metabolites and lipids applying UHPLC-MS clinical metabolic phenotyping assays

Metabolic phenotyping of tissues uses metabolomics and lipidomics to measure the relative polar and non-polar (lipid) metabolite levels in biological samples. This approach aims to understand disease biochemistry and identify biochemical markers of disease. Sample preparation methods must be repr...

2020-09-28 | MTBLS1707 | MetaboLights
UnknownIncreased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies.
Not available
S-EPMC8897585 | biostudies-literature
UnknownConvergent validity and reliability of a novel repeated agility protocol in junior rugby league players.
Not available
S-EPMC8577058 | biostudies-literature
MetabolomicsCoupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell Renal Cell Carcinoma (ccRCC) stage I, II, III, and IV (n=112) and controls (n=52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spec...

2020-11-20 | MTBLS1839 | MetaboLights
UnknownBody mass index and causes of death in chronic kidney disease.
Not available
S-EPMC4757850 | biostudies-literature
MetabolomicsPostoperative Metabolic Phenoreversion in Clear Cell Renal Cell Carcinoma

The ultimate goal of surgical treatment in cancer is to remove the tumor mass for restoring a healthy state. A 16-lipid panel that discriminated healthy controls from clear cell renal cell carcinoma (ccRCC) patients in a prior study was evaluated in the present work in paired-serum samples collec...

2023-01-02 | MTBLS3838 | MetaboLights
UnknownA Whole-Grain Diet Improves Whole-Body Protein Turnover Compared to a Macronutrient-Matched Refined-Grain Diet in Adults with Overweight/Obesity
Not available
S-EPMC7258952 | biostudies-literature
MetabolomicsDirect infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control
Direct-infusion mass spectrometry (DIMS) metabolomics is an important approach for characterising molecular responses of organisms to disease, drugs and the environment. Increasingly large-scale metabolomics studies are being conducted, necessitating improvements in both bioanalytical and computatio...
2022-05-16 | MTBLS79 | MetaboLights
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