Increased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies.

ABSTRACT:

Background

Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene signatures, and assessed the effect of bariatric surgery.

Methods

We compared the number, function, and gene expression profiles of circulating LDN in morbidly obese patients (MOP, n=27; body mass index (BMI) > 40 Kg/m²) and normal-weight controls (NWC, n=20; BMI < 25 Kg/m²) in a case-control study. Additionally, in a prospective longitudinal study, we measured changes in the frequency of LDN after bariatric surgery (n=36) and tested for associations with metabolic and inflammatory parameters.

Findings

LDN and in

SUBMITTER: Sanchez-Pino MD 

PROVIDER: S-EPMC8897585 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature