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TranscriptomicsA Xenopus DNA microarray approach to identify novel direct BMP target genes involved in early embryonic development
Bone Morphogenetic Proteins (BMPs), a subgroup of the TGF- superfamily, were originally isolated from bone on the basis of their ability to induce ectopic bone development. While BMPs are involved in a wide range of developmental and physiological functions, very few vertebrate target genes in t...
ORGANISM(S): Xenopus laevis 
2010-06-10 | E-GEOD-2274 | biostudies-arrayexpress
TranscriptomicsIdentification of neural genes using Xenopus DNA microarrays
In order to isolate novel genes regulating neural induction, we utilized a DNA microarray approach. As neural induction is thought to occur via the inhibition of BMP signaling, BMP signaling was inhibited in ectodermal cells by overexpression of a dominant-negative receptor. RNAs were isolated from...
ORGANISM(S): Xenopus laevis 
2010-06-10 | E-GEOD-2266 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated by XOct-25 overexpression in Xenopus ectoderm
The Xenopus POU class V transcription factor XOct-25 has been shown to inhibit BMP-dependent epidermal differentiation and promote neural induction in the ectoderm during early embryogenesis. In order to identify genes that act downstream of XOct-25, transcriptional profile of Xenopus ectodermal ce...
ORGANISM(S): Xenopus laevis 
2012-10-05 | E-GEOD-24562 | biostudies-arrayexpress
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