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ProteomicsOrthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
Protein ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2, and ubiquitin ligase E3. Uba1 was thought to be the only E1 until the recent identification of Uba6 as an alternative. To differentiate the biological functions of Uba1 and Uba6, we ap...
ORGANISM(S): Homo sapiens (Human) 
2017-07-31 | PXD005513 | Pride
Lc-msms Ubiquitination Ubiquitin 
ProteomicsOrthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin enzymes
Protein ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2, and ubiquitin ligase E3. Uba1 was thought to be the only E1 until the recent identification of Uba6 as an alternative. To differentiate the biological functions of Uba1 and Uba6, we ap...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005500 | Pride
Lc/ms Ubquitin 
TranscriptomicsComparative genomic hybridization of mouse cell lines MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4767 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4114 | biostudies-arrayexpress
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