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ProteomicsIdentification of MHC ligands through allele guided isolation combined with machine learning for specific MHC assignment
Isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for T cell-based immunotherapies. However, as many targets of high tumor-specificity are only presented at low abundance on the cell surface of tumor cells, the efficient isolat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD061101 | Pride
Hla assignment Machine learning Immunopeptidome 
ProteomicsAberrant SUMOylation restricts the targetable cancer immunopeptidome
A balanced SUMOylation equilibrium safeguards the functional anti-tumor immune response. Oncogene activation drives SUMOylation, rendering aberrant SUMOylation a hallmark of cancer. To delineate the impact of activated SUMOylation on the tumor-immune synapse, we applied HLA class-I-targeted ligandom...
ORGANISM(S): Homo sapiens (Human) 
2026-01-25 | PXD061196 | Pride
Sumoylation Immunpeptidome 
ProteomicsLow-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC ligands as Potential Targets for Cancer Immunotherapy
Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by the qualitative and quantitative changes in human leukocyte antigen (HLA) ligands on the cancer cell surface. We investigated the effects of CDK4/6i, Abema...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024965 | Pride
Abemaciclib Palbociclib Breast cancer Cdk4/6 inhibition Mhc ligand 
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