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TranscriptomicsRestoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably ...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-36941 | biostudies-arrayexpress
TranscriptomicsSystems analysis of uterine microenvironment in Treg depleted pregnant mice at 12 days after fertilization
Analysis of uterine microenvironment at gene expression level. The hypothesis tested in the present study was that Tregs orchestrated the immune reponse triggered in presence of embryo. Total RNA obtained from uterine microenvironment tissues of Treg depleted pregnant mice (12 days after fertilizati...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-68432 | biostudies-arrayexpress
TranscriptomicsSystems analysis of uterine microenvironment 4, 6, 8, 10, 11 or 12 days after fertilization
Analysis of uterine microenvironment at gene expression level. The hypothesis tested in the present study was that Tregs orchestrated the immune reponse triggered in presence of embryo Total RNA obtained from uterine microenvironment tissues (4, 6, 8, 10, 11 or 12 days after fertilization) compared ...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-68433 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_IFN]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53467 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53469 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [RVPC3_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53465 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53466 | biostudies-arrayexpress
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