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TranscriptomicsTranscription profiling of human HNF1beta mutated vs wildtype embryonic kidney cell line HEK293 to identify potential HNF1beta target genes whose activity may be deregulated in human patients
Hepatocyte nuclear factor 1beta (HNF1beta, TCF2) is a tissue-specific transcription factor whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy and maturity onset diabetes of the young (MODY5). Furthermore, HNF1beta overexpression has been observed in clear cell can...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-3308 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat insulinoma INS-1 cell lines (FLP-In T-REx)
Four rat insulinoma cell lines (INS-1) were generated that contain a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the cell lines contain the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene e...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1591 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Rattus norvegicus pancreatic beta cell line expressing HNF1b, HNF4a2 or HNF6
This SuperSeries is composed of the following subset Series:; GSE1589: Targets of HNF1b, HNF4a2 and HNF6 in INS-1 cells; GSE1590: Targets of HNF1b mutants in INS-1; GSE1591: INS-1 cell lines (FLP-In T-REx) Experiment Overall Design: Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-6428 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat insulinoma line INS-1 to identify targets of HNF1b mutants in INS-1
A rat insulinoma cell line (INS-1) was generated that contains a FRT site for FLP recombinase mediated site specific integration of specific genes. In addition, the line contains the tetracycline repressor allowing tetracycline (tet) induction of the introduced gene. By comparing the gene expression...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1590 | biostudies-arrayexpress
UnknownA machine learning method for the identification and characterization of novel COVID-19 drug targets.
Not available
S-EPMC10156718 | biostudies-literature
UnknownThe transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells
Not available
S-SCDT-10_1038-S44318-025-00642-7 | biostudies-other
UnknownRivaroxaban vs Vitamin K Antagonist in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease.
Not available
S-EPMC11198259 | biostudies-literature
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