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TranscriptomicsThe effects of moderate weight gain in adipose tissue gene expression in metabolically-normal (MNO) and metabolically-abnormal (MAO) subjects
Obesity is associated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, which are key risk factors for diabetes and cardiovascular disease. However, a subset of obese people does not develop these metabolic complications. We tested the hypothesis that MNO, but not MAO, ...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-62832 | biostudies-arrayexpress
TranscriptomicsThe effect of progressive weight loss on metabolic function
The purpose of this study was to evaluate the effect of progressive weight loss (5, 10, 15% weight loss) on metabolic function such as multi-organ insulin sensitivity and beta-cell function in obese people. We conducted microarray analysis to determine the effect of progressive weight loss on adipos...
ORGANISM(S): Homo sapiens 
2016-02-26 | E-GEOD-70529 | biostudies-arrayexpress
UnknownIdentification of germline genomic copy number variation in familial pancreatic cancer.
Not available
S-EPMC3808836 | biostudies-literature
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownVariability in thermal and phototactic preferences in Drosophila may reflect an adaptive bet-hedging strategy.
Not available
S-EPMC5063146 | biostudies-literature
TranscriptomicsTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
The cone-rod homeobox gene (Crx) encodes Crx, a transcription factor selectively expressed in two cell types, retinal photoreceptors and the melatonin secreting pinealocytes of the pineal gland. In this report the role of Crx in regulating gene expression in the mammalian pineal gland was extended u...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-24625 | biostudies-arrayexpress
UnknownTwo alternating motor programs drive navigation in Drosophila larva.
Not available
S-EPMC3156121 | biostudies-literature
TranscriptomicsWhole transcriptome profiling of rat pineal glands and retinas collected throughout a 24-hour cycle
The rat pineal transcriptome is highly dynamic, with many hundreds of transcripts changing more than two-fold on a 24-hr basis, as revealed earlier using Affymetrix GeneChip analysis. The retina is evolutionally related to the pineal gland so these two tissues share many gene expression patterns. Th...
ORGANISM(S): Rattus norvegicus 
2014-02-05 | E-GEOD-46069 | biostudies-arrayexpress
UnknownAssociation Between COVID-19 During Pregnancy and Preterm Birth by Trimester of Infection: Retrospective Cohort Study Using Large-Scale Social Media Data.
Not available
S-EPMC12266298 | biostudies-literature
UnknownIntegrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome.
Not available
S-EPMC5047668 | biostudies-literature
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