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TranscriptomicsNovel roles for Klf1 in regulating the erythroid transcriptome revealed by mRNA-seq
Klf1 (formerly known as Eklf) regulates the development of erythroid cells from bi-potent progenitor cells via the transcriptional activation of a diverse set of genes. Mice lacking Klf1 die in utero prior to E15 from severe anemia due to the inadequate expression of genes controlling hemoglobin pro...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-33979 | biostudies-arrayexpress
TranscriptomicsKLF1, KLF2 and c-myc control a regulatory network essential for embryonic erythropoiesis
The Krüppel-like factors, KLF1 and KLF2, positively regulate embryonic β-globin expression, and have additional overlapping roles in embryonic (primitive) erythropoiesis. KLF1-/-KLF2-/- double knockout mice are anemic at embryonic day 10.5 (E10.5) and die by E11.5, in contrast to single knockouts. T...
ORGANISM(S): Mus musculus 
2012-03-12 | E-GEOD-36427 | biostudies-arrayexpress
GenomicsKLF1/EKLF regulatory networks in primary erythroid cells
KLF1 (EKLF) regulates a diverse suite of genes to direct erythroid cell differentiation from bi-potent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse. We found at least 945 sites in the gen...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-20478 | biostudies-arrayexpress
TranscriptomicsExpression profiling of mouse CD4+ T cells following Klf1 retrovirus vector transfection
Krüppel-like factor 1 (Klf1) is a transcription factor that promotes β-globin synthesis in erythroid progenitors, and its role in immunological homeostasis is unknown. The full-length mRNA of mouse Klf1(NM-010635) was cloned into the pMIG retroviral vector, which contains an IRES-GFP cassette. Splen...
ORGANISM(S): Mus musculus 
2018-05-10 | E-MTAB-6778 | biostudies-arrayexpress
GenomicsMus musculus strain:Klf1
Klf1-Nan Developmental Course Comparative Transcriptome
PRJNA432205 | ENA
ProteomicsKLF1-activated macrophages proteomic analysis
In this project we did a proteomic analysis from iPSCs-derived macrophages with the activation of thranscription factor KLF1, upon tamoxifen induction. These macrophages are a model for the study of the erythroid island (EI) niche in adult hematopoietic tissues, such as bone marrow and spleen. We wa...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050357 | Pride
Macrophages Erythroid island niche Ipscs Proteomics Klf1 
GenomicsKLF1 haploinsufficiency
Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
PRJEB31712 | ENA
GenomicsRNA-sequencing comparing activation of wild-type transcription factor KLF1 with mutant KLF1 (KLF1-325K) in iPSC-derived macrophages.
RNA-sequencing comparing activation of wild-type transcription factor KLF1 with mutant KLF1 (KLF1-325K) in iPSC-derived macrophages.
PRJNA950312 | ENA
TranscriptomicsMicroarray analysis of wildtype and Klf1-/- E13.5 fetal liver
The aim of this experiment was to investigate the role of KLF1 in the fetal liver Affymetrix microarrays were performed on fetal liver cells from E13.5 wildtype and Klf1-/- mice. Three wildtype replicates and three Klf1-/- replicates, all from E13.5 fetal liver.
ORGANISM(S): Mus musculus 
2012-02-07 | E-GEOD-35594 | biostudies-arrayexpress
GenomicsMouse Klf1 Nan variant fetal liver analysis
The mouse Klf1 Nan variant impairs nuclear condensation and erythroid maturation
PRJEB30678 | ENA
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