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TranscriptomicsAlkbh1/Tzfp Repress a Non-Repeat piRNA Cluster in Pachytene Spermatocytes
Piwi proteins and Piwi-interacting small RNAs (piRNAs) have known functions in transposon silencing in the male germline of fetal and newborn mice. Both are also necessary for spermatogenesis in adult testes, however, their function here remains a mystery. Here, we use germ cell isolations and small...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-37150 | biostudies-arrayexpress
TranscriptomicsTestis samples from Alkbh1 wild-type and KO mice
The aim of the study was to elucidate the role of Alkbh1 by targeted deletion in C57/BL6 mice. Alkb deficiency results in sex-ratio distortion of offspring and apoptosis in adult testes, most likely caused by defects in the pachytene stage during spermatogenesis. Due to the pivotal role of Alkbh1 in...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22073 | biostudies-arrayexpress
UnknownThe RNA m6A landscape during human oocyte-to-embryo transition
RNA N6-methyladenosine (m6A, m6A) modification is a critical regulator for a range of physiological processes. However, the dynamic m6A profiles within human preimplantation embryos remain uncharacterized. Here, we present the first RNA m6A landscape of single human oocytes and early embryos. Compar...
S-SCDT-10_1038-S44318-025-00474-5 | biostudies-other
UnknownCDK12/CDK13 inhibition disrupts transcriptional elongation and fork progression in glioblastoma
Glioblastomas are the most prevalent and aggressive malignant brain tumors, characterized by hypertranscription and dependence on neurodevelopmental transcription factors. The transcriptional cycle is regulated by phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII) by transc...
S-SCDT-10_1038-S44321-026-00393-W | biostudies-other
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