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Metabolomics1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients
Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO2). We used pr...
2020-11-10 | MTBLS1894 | MetaboLights
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
TranscriptomicsGenome-wide DNA methylation study of hip and knee osteoarthritic and healthy cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis
Cartilage samples were collected from hip or knee joint replacement patients either due to primary OA or hip fractures as controls. DNA was extracted from the collected cartilage and assayed by Illumina Infinium HumanMethylation450 ‎BeadChip array, which allows for the analysis of >480,000 CpG sit...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-73626 | biostudies-arrayexpress
TranscriptomicsRNA-seq of synovial biopsies from rheumatoid arthritis patients
Synovial biopsies from rheumatoid arthritis patients were obtained and profiled using RNA-seq. Patients were stratified according to the number of swollen joints they had (SJC, swollen joint count) and divided in three groups for the differential expression analysis: None (SJC = 0), Low (1<= SJC <= ...
ORGANISM(S): Homo sapiens 
2021-04-26 | E-MTAB-6684 | biostudies-arrayexpress
TranscriptomicsOsteoarthritis-related changes in gene expression in knee articular chondrocytes in a rat model of osteoarthritis.
Cartilage destruction in osteoarthritis (OA) results from disturbed chondrocyte metabolism. Here, we used microarrays to show that TGF alpha and CCL2 are simultaneously upregulated in a rat model of OA and cooperate to drive cartilage degradation. The goals of the experiments included here were to a...
ORGANISM(S): Rattus norvegicus 
2012-11-15 | E-GEOD-42295 | biostudies-arrayexpress
ProteomicsFGA can be used as a promising therapeutic target in osteoarthritis
Twenty-six patients who underwent knee joint surgery at the Department of Orthopedics from January 2023 to December 2023 were selected. OA knee cartilage extracted during surgery was included in the experimental group, and normal knee cartilage extracted during surgery was included in the control gr...
ORGANISM(S): Homo Sapiens 
PXD063166 |
TranscriptomicsRNA-Seq analysis of human osteoarthritic intact cartilage following total knee replacement
Large scale RNA-Seq analysis was performed to investigate the transcriptomic response to osteoarthritis in cartilage and investigate potential subgroups of patients. Data were collected from intact knee cartilage (posterior lateral condyle) from at total of 60 patients with osteoarthritis (OA) follo...
ORGANISM(S): Homo sapiens 
2017-12-13 | E-MTAB-6266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse knee joint synovium from different grades of inflammation in mouse collagen induced arthritis (CIA)
Knee joint synovium was used for gene expression analysis of mouse collagen induced arthritis (CIA). Synovium was prepared at day 30 after initial sensitization from: healthy controls, CIA animals with no, with mild, with moderate, or with severe joint inflammation. Each sample group is represente...
ORGANISM(S): Mus musculus 
2009-09-15 | E-GEOD-13071 | biostudies-arrayexpress
TranscriptomicsHuman transcripts up-regulated in the human mesenchymal stem cells migrated within the synovium
After the injection of human synovial mesenchymal stem cells into the rat (Lewis strain) knee joint, synovium was investigated using species specific microarray analyses of human and rat transcripts to investigate the gene expression change after injection. Human synovial mesenchymal stem cells were...
ORGANISM(S): Homo sapiens 
2014-09-22 | E-GEOD-61617 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomics of rat knee-joint tissue in a monosodium-iodoacetate osteoarthritis model treated with the Ayurvedic formulations
Osteoarthritis (OA) causes progressive cartilage and bone degradation for which no disease-modifying therapy exists. Withania somnifera (WS) and Yogaraj Guggulu (YG) are centuries-old herbal formulation used in Ayurveda for joint disorders, but its molecular mode of action is poorly defined. We perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-19 | PXD065118 | Pride
Yogaraj guggulu Label-free proteomics Orbitrap eclipse Rattus norvegicus Osteoarthritis  withania somnifera Knee joint Data-dependent acquisition Lc-ms/ms 
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