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TranscriptomicsGene expression profiles of human immature dendritic cells after 3h, 6h and 12h of co-cultivation with Aspergillus fumigatus
Gene expression profiles of human immature dendritic cells after 3h, 6h, 9h and 12h of co-cultivation with Aspergillus fumigatus were compared to expression profiles from human immature dendritic cells after 3h, 6h, 9h and 12h of cultivation. We used microarrays to detail the gene expression of huma...
ORGANISM(S): Homo sapiens 
2011-03-29 | E-GEOD-21353 | biostudies-arrayexpress
TranscriptomicsAgilent data from Arabidopsis thaliana enriched guard cell tissue and leafs.
To identify genes of the guard cell transcriptome of Arabidopsis thaliana enriched guard cell samples were compared with total leaf tissue. Genes of the abscisic acid and humidity response of Arabidopsis thaliana guard cells were identified by treatment with ABA-Spray and low humidity. total samples...
ORGANISM(S): Arabidopsis thaliana 
2013-01-14 | E-GEOD-41054 | biostudies-arrayexpress
TranscriptomicsMutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors
Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find novel therapeutic leads for this subgroup of patients, we analyzed 58 blastemal-type Wilms tumors by exome and transcriptome sequ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60081 | biostudies-arrayexpress
TranscriptomicsDendritic cell maturation by proinflammatory TNF or pathogenic Trypanosoma brucei antigens instruct similar T helper-2 cell responses in murine models of autoimmunity and asthma
Background Dendritic cells (DC) represent the major cell type leading to polarized T helper (Th) cell responses in vivo. The current data indicate that DC maturation under inflammatory conditions or by helminth infections induce only incomplete DC maturation bearing a partially tolerogenic potential...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-28231 | biostudies-arrayexpress
TranscriptomicsSex-specific effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions
prenatal stress response, genetic modification Background: Prenatal stress (PS) exposure has been shown to increase the risk for emotional disorders in later life. Furthermore, the serotonin transporter (5-HTT) genotype is suggested to exert a modulating effect on the association between early life ...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-26025 | biostudies-arrayexpress
TranscriptomicsStreptococcus agalactiae induced gene expression in human coronar artery endothelial cells
Early onset sepsis due to Group B streptococcus (GBS) leads to neonatal morbidity, increased mortality and long term neurological deficencies. Interaction between septicemic GBS and confluent monlayers of human coronary artery endothelial cells (HCAEC) was analyzed by a genome wide expression profil...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-15495 | biostudies-arrayexpress
TranscriptomicsMyc and Miz-1 control melanocyte senescence by regulating intracellular cystathionase levels
The development of malignant melanoma is a highly complex process which is still poorly understood despite extensive research. A majority of human melanomas are found to express a handful of oncogenic proteins, such as mutant RAS and BRAF. However, these oncogenes are also found in nevi, and it is n...
ORGANISM(S): Mus musculus 
2012-07-02 | E-GEOD-30473 | biostudies-arrayexpress
GenomicsHey target gene regulation in murine ES cells and cardiomyocytes [high throughput sequencing]
We used an in vitro cardiomyocyte differentiation system with inducible Hey1 or Hey2 expression to study target gene regulation in cardiomyocytes (CM) generated from murine embryonic stem cells (ESC). The effects of Hey1 and Hey2 are largely redundant, but cell type specific. The number of regulated...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-60699 | biostudies-arrayexpress
TranscriptomicsHey target gene regulation in murine ES cells and cardiomyocytes [Affymetrix]
We used an in vitro cardiomyocyte differentiation system with inducible Hey1 or Hey2 expression to study target gene regulation in cardiomyocytes (CM) generated from murine embryonic stem cells (ESC). The effects of Hey1 and Hey2 are largely redundant, but cell type specific. The number of regulated...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-60746 | biostudies-arrayexpress
TranscriptomicsDifferential accumulation of splice variants and transcripts as a result of PI3K inhibition in T lymphocytes and the potential role of their gene products in T cell silencing
Using measles virus induced T cell suppression as a model, we established that T cell inhibitory protein isoforms can be produced from alternatively spliced pre-mRNAs as a result of virus-mediated ablation of T cell receptor dependent activation of the phosphatidylinositol-3-kinase (PI3K). To asses ...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-38255 | biostudies-arrayexpress
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