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TranscriptomicsGene expression profiling of imatinib-treated and untreated human Hematopoetic progenitors expressing the ETV6-PDGFRB oncogene
In order to investigate the mechanism whereby TEL-PDGF-beta (ETV6-PDGFRB) interferes with human hematopoietic progenitors proliferation and differentiation, we analyzed the gene expression response downstream this oncogene. CD34+ cells infected with lentivirus coding for TEL-PDGFRb were cultured for...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-28698 | biostudies-arrayexpress
UnknownDistinct and Specific Role of NlpC/P60 Endopeptidases LytA and LytB in Cell Elongation and Division of Lactobacillus plantarum.
Not available
S-EPMC6473061 | biostudies-literature
UnknownJAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation.
Not available
S-EPMC12340059 | biostudies-literature
UnknownOncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.
Not available
S-EPMC3105646 | biostudies-literature
UnknownLoss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases.
Not available
S-EPMC11108519 | biostudies-literature
TranscriptomicsGene expression after type-I interferon treatment in primary neurons, primary fibroblasts and L929 cells
Microarray expression profilling of mouse primary mixed cortical/hippocampal neurons, primary fibroblasts and L929 cells to compare ISGs signature in disctinct cell types Primary mixed cortical/hippocampal neurons, primary fibroblasts (MEFs) and L929 cells were mock-treated or treated with 5U/mL of ...
ORGANISM(S): Mus musculus 
2014-01-10 | E-GEOD-53951 | biostudies-arrayexpress
MetabolomicsHomeostasis of the biosynthetic E. coli metabolome
Metabolite concentrations vary across conditions and such metabolome changes are relevant for metabolic and gene regulation. Here, we used LC-MS/MS to explore metabolite concentration changes in Escherichia coli. We measured 101 primary metabolites in 19 experimental conditions that include v...
2022-11-02 | MTBLS4249 | MetaboLights
UnknownInefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
Not available
S-EPMC3993554 | biostudies-literature
UnknownTranscription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data.
Not available
S-EPMC2887972 | biostudies-literature
TranscriptomicsTranscription profiling of human JAK1 wild-type and JAK1 mutation-positive T cell acute lymphoblastic leukemia blasts
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and diff...
ORGANISM(S): Homo sapiens 
2009-10-02 | E-GEOD-18239 | biostudies-arrayexpress
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