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TranscriptomicsTranscriptome Sequencing (RNA-seq) of Ara-C Resistant Murine AML Cell Lines Identifies Mechanisms of Resistance
An RNA-seq study of altered gene expression and mutations in Ara-C resistant acute myeloid leukemia murine cell lines. The analysis of the RNA-seq data led to the identification of a large deletion within the Dck coding sequence of the B117H cell line, which produced an alternatively processed form...
ORGANISM(S): Mus musculus 
2014-08-13 | E-GEOD-47454 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mice TRAF2/Casp-8LPC-KO tumors
This model was used to study the relationship between NF-kB and PCD regulation and generated mice with combined conditional ablation of Traf2 and Caspase-8 (TRAF2/Casp-8LPC-KO) in order to block apoptosis and specifically study the role of necroptosis in Traf2-deficient hepatocytes in vivo.
ORGANISM(S): Mus musculus 
2019-05-31 | E-MTAB-4598 | biostudies-arrayexpress
UnknownUsing RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia.
Not available
S-EPMC4131221 | biostudies-literature
TranscriptomicsDevelopment of a Neural Teratogenicity Test Based on Human Embryonic Stem Cells- Response to Retinoic Acid Exposure
The aim of this study was the development of an alternative testing method based on human embryonic stem cells for prenatal developmental toxicity with particular emphasis on early neural development. To this purpose, we designed an in vitro protocol based on the generation of neural rosettes, repre...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-MEXP-3577 | biostudies-arrayexpress
UnknownThe susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity.
Not available
S-EPMC6151916 | biostudies-literature
UnknownAssociation between Sagittal Cervical Spinal Alignment and Degenerative Cervical Spondylosis: A Retrospective Study Using a New Scoring System.
Not available
S-EPMC8999493 | biostudies-literature
TranscriptomicsTranscription profiling of human T-cell lymphoblastic leukemia, acute mylelogenous leukemia and Diffuse Large Cell Lymphoma cell lines after treatment with aplidin and/or cytarabine
Aplidin (plitidepsin) is a novel antitumor agent isolated from the Mediterranean tunicate Aplidium albicans. Aplidin has shown impressive in vitro and in vivo activity against various cancer cell lines. Based on the results from several laboratories Aplidin has recently been granted orphan drug desi...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-5681 | biostudies-arrayexpress
ProteomicsNeddylation of Insulin receptor substrate acts as a bona fide suppressor for cancer cell migration
Hyperinsulinemia, often associated with obesity and type 2 diabetes mellitus, is also linked to an elevated risk of various cancers. However, the specific mechanisms underlying this connection remain unclear. Here, we report that inhibiting neddylation, in the presence of insulin treatment, further ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD044760 | Pride
Lc-ms/ms 
UnknownDiagnostic Accuracy of Magnetic Resonance Imaging for Sagittal Cervical Spine Alignment: A Retrospective Cohort Study.
Not available
S-EPMC8702200 | biostudies-literature
TranscriptomicsEpiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
Embryonic stem cells (ESCs) comprise at least two populations of cells with divergent states of pluripotency. Here, we show that epiblast stem cells (EpiSCs) also comprise two distinct cell populations that can be distinguished by the expression of a specific Oct4-GFP marker. These two subpopulation...
ORGANISM(S): Mus musculus 
2011-02-24 | E-GEOD-17984 | biostudies-arrayexpress
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