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ProteomicsSecretome and Proteome of WT and CFTR-KO pancreatic duct epithelial cells
Loss of CFTR function in the pancreatic duct leads to dysregulated luminal pH causing premature activation of digestive enzymes and tissue necrosis. Drastic alterations in pancreatic tissue architecture and cellular composition changes the microenvironment of the islets. Given that CFTR is expressed...
ORGANISM(S): Mustela putorius furo (European domestic ferret) (Mustela furo) 
2021-05-27 | PXD025126 | Pride
Pancreas Cystic fibrosis Cystic fibrosis related diabetes Ductal cells Proteome Secretome 
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
UnknownCardiac intervention rates for older patients with acute myocardial infarction in the United States and Ontario, 2003-2013: a retrospective cohort study.
Not available
S-EPMC7850174 | biostudies-literature
UnknownUnexpectedly High Levels of Inverted Re-Insertions Using Paired sgRNAs for Genomic Deletions.
Not available
S-EPMC7565582 | biostudies-literature
TranscriptomicsATAC-sequencing mice small intestinal epithelium with intestinal epithelium specific LSD1 knock out compared to wild type
To study the epigenetic regulation of intestinal epithelium we focus on the role of chromatin modulators. Lysine-specific histone demethylase 1a (KDM1A, LSD1) is one of the enzymes that can erase the H3K4me1/2 mark. To assess the role of LSD1 in intestinal epithelium we studied wild type (WT) (Villi...
ORGANISM(S): Mus musculus 
2021-03-23 | E-MTAB-8718 | biostudies-arrayexpress
UnknownEstablishing Equivalent Aerobic Exercise Parameters Between Early-Stage Parkinson's Disease and Pink1 Knockout Rats.
Not available
S-EPMC9535586 | biostudies-literature
UnknownPresence of the Paternal Pronucleus Assists Embryo in Overcoming Cycloheximide Induced Abnormalities in Zygotic Mitosis.
Not available
S-EPMC4909515 | biostudies-literature
UnknownModulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.
Not available
S-EPMC6012490 | biostudies-literature
ProteomicsUnbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in SCLC
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, inhibits SCLC expansion in culture and in vivo. Conversely, GNAS (G-protein ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-17 | PXD018209 | Pride
Inhibitor beads Analog specific Kinase proteomics Small cell lung cancer 
UnknownCalpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.
Not available
S-EPMC3783572 | biostudies-literature
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