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TranscriptomicsKnockout mice reveal key roles for claudin-18 in alveolar fluid homeostasis.
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJ), where they serve as regulators of paracellular permeability to ions and solutes. Claudin-18, a member of the large claudin family, is highly expressed in lung epithelium. To elucidate the role of claudin-18 i...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-48443 | biostudies-arrayexpress
ProteomicsLiver samples from WT and Atg7 liver specific KO mice
iTRAQ proteomics was performed for Liver samples from WT and Atg7 liver specific KO mice
ORGANISM(S): Mus Musculus 
2023-07-20 | PXD043936 |
TranscriptomicsTranscription profiling of E12.5 mouse whole embryos and placentas pooled within 3 litters to validate a new array
E12.5 mouse whole embryos and placentas were pooled within 3 litters and total RNA was extracted. Fluorescently-labeled, linearly-amplified cRNA targets were prepared from the RNA samples and compared on a novel microarray design to validate the system. A "dye-swapped" experimental design was used t...
ORGANISM(S): Mus musculus 
2005-01-01 | E-MNIA-69 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E12.5 mouse whole embryos and placentas pooled within 3 litters and used to valdiate a new array
E12.5 mouse whole embryos and placentas were pooled within 3 litters and total RNA was extracted. Fluorescently-labeled, linearly-amplified cRNA targets were prepared from the RNA samples and compared on a novel microarray design to validate the system. A "self-versus-self" experimental design was u...
ORGANISM(S): Mus musculus 
2005-01-01 | E-MNIA-68 | biostudies-arrayexpress
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
UnknownNpy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.
Not available
S-EPMC5055068 | biostudies-literature
GenomicsGenome-wide DNA methylation analyses by the MeDIP assay
We analyzed the genome-wide DNA methylation in Zscan4 overexpressing ES cells. Zscan4 overexpression induced slight DNA demethylation in telomere and major satellite regions. Subsequent genome-wide analysis of non-repeated regions revealed the significant reduction of DNA methylation at Zscan4-depen...
ORGANISM(S): Mus musculus 
2015-09-10 | E-GEOD-58618 | biostudies-arrayexpress
UnknownProtective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis.
Not available
S-EPMC6546013 | biostudies-literature
UnknownLack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models.
Not available
S-EPMC11141868 | biostudies-literature
TranscriptomicsGenome-wide transcriptome analyses by the RNA-seq method
We performed the whole transcriptome analysis in Zscan4 positive ES cells (Em+) and Zscan4 negative ES cells (Em-) by using FACS-sorted MC1-ZE7 ES cells. Whole RNA-seq in Zscan4 positive and negative cells
ORGANISM(S): Mus musculus 
2015-09-10 | E-GEOD-58619 | biostudies-arrayexpress
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