An in vitro prepared NTSR1-Arr2 complex was stabilized by use of heterobifunctional crosslinker. Here we characterize the crosslinks observed upon photo-illumination of this complex.
Most drugs acting on G-protein-coupled receptors target the orthosteric binding pocket where the native hormone or neurotransmitter binds. There is much interest in finding allosteric ligands for these targets because they modulate physiologic signaling and promise to be more selective than orthoste...
