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TranscriptomicsM-NM-2-Cryptoxanthin suppresses inflammatory gene expression in diet-induced nonalcoholic steatohepatitis in mice
To evaluate the effect of M-NM-2-cryptoxanthin on diet-induced NASH, we fed a high-cholesterol and high-fat diet (CL diet) with or without 0.003% M-NM-2-cryptoxanthin to C56BL/6J mice for 12 weeks. After feeding, M-NM-2-cryptoxanthin attenuated fat accumulation, increases in Kupffer and activated st...
ORGANISM(S): Mus musculus 
2014-05-28 | E-GEOD-51432 | biostudies-arrayexpress
TranscriptomicsQuercetin suppresses immune cell accumulation and improves mitochondrial gene expression in epididymal adipose tissue of diet-induced obese mice
We examined the effect of quercetin on the gene expression and function of epididymal adipose tissue (EAT) in Western diet-induced obese mice. Quercetin suppressed the increase in the number of macrophages and the decrease in the ratio of CD4+ to CD8+ T cells in EAT, and the elevation of plasma lept...
ORGANISM(S): Mus musculus 
2016-02-25 | E-GEOD-71367 | biostudies-arrayexpress
TranscriptomicsPhloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice
We previously showed that a diet containing phloridzin suppressed the blood glucose levels in streptozotocin-induced diabetic mice most likely by inhibiting glucose absorption from the small intestine. In this study, we showed that 0.5% and 1% phloridzin diets significantly reduce the blood glucose ...
ORGANISM(S): Mus musculus 
2012-05-17 | E-GEOD-37415 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in streptozotocin-induced diabetic mice fed a quercetin diet
Quercetin is a food component that may ameliorate the diabetic symptoms. We examined hepatic gene expression of BALB/c mice with streptozotocin (STZ)-induced diabetes to elucidate the mechanism of the protective effect of dietary quercetin on diabetes-associated liver injury. We fed STZ-induced dia...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38067 | biostudies-arrayexpress
Transcriptomicstranscription profiling by array of C57BL/6J mice fed a Western-style diet with or without 0.05% quercetin against mice on a control diet to study the effect of quercetin on obesity and hepatic gene expression
To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression, C56BL/6J mice were fed for 20 weeks on control or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Chronic dietary intake of quercetin reduce...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-38141 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in streptozotocin-induced diabetic mice fed a phloridzin diet
Phloridzin is a dihydrochalcone typically contained in apples. A diet containing 0.5 % phloridzin significantly improves hyperglycemia but not hypoinsulinemia and tissue lipid peroxidation in streptozotocin (STZ)-induced diabetic mice after 14 days. The phloridzin diet has no effect on the alteratio...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-38138 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in BALB/c mice fed a quercetin diet
We showed that diets containing 0.1% or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels. A cluster analysis of the hepatic gene expressions showed that 0.5% quercetin diet suppressed STZ-induced alteration of gene expression. Gene set enri...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-38136 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression in C56BL/6J mice fed a quercetin diet for 20 weeks
Both the 0.05% and 1% querceitn diets did not significantly affect the body weight, fat accumulation, and blood components. However, 0.05% quercetin significantly increased the glutathione/oxidized glutathione ratio in the liver. Moreover, the 1% quercetin diet reduced the lipid peroxidation markers...
ORGANISM(S): Mus musculus 
2015-07-24 | E-GEOD-62805 | biostudies-arrayexpress
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