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TranscriptomicsRNA-seq of Mycobacterium tuberculosis H37Rv treated with alpibectir or a combination of alpibectir and ethionamide against untreated controls
Alpibectir potentiates the activity of ethionamide and prothionamide, which are second-line antibiotics used for tuberculosis treatment. Both are prodrugs whose antibacterial activity depends on bioactivation by oxidases, including the Baeyer-Villiger monooxygenase MymA. Alpibectir binds the transcr...
ORGANISM(S): Mycobacterium tuberculosis 
2025-12-10 | E-MTAB-16253 | biostudies-arrayexpress
TranscriptomicsEngagement of the aryl hydrocarbon receptor in M. tuberculosis-infected macrophages has pleiotropic effects on innate immune signaling
Understanding the mechanisms of host macrophage responses to M. tuberculosis (M.tb.) is essential for uncovering potential avenues of intervention to boost host resistance to infection. Macrophage transcriptome profiling revealed M.tb. infection strongly induced expression of several enzymes control...
ORGANISM(S): Homo sapiens 
2015-07-14 | E-GEOD-70200 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart left ventricles from 15 week old inbred COP, DA, and F1(COP x DA) offspring with respect to aerobic running capacity (low, high, and intermediate performers respectively)
We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these tw
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1795 | biostudies-arrayexpress
ProteomicsDisease-linked lysine glutarylation impairs function and interactions of mitochondrial proteins and contribute to mitochondrial heterogeneity
Inherited deficiencies of the lysine and tryptophan catabolic pathways, due to mutations in the glutaryl-CoA-dehydrogenase (GCDH) gene, cause glutaric aciduria type 1 (GA1). In mammals two metabolic routes for L-lysine oxidation exist, the mitochondrial saccharopine pathway, which is predominant in ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD007881 | Pride
Metabolism Molecular biology of disease Protein interaction Glutaryl-coa-dehydrogenase Glutaryl-proteome Proteolysis & proteomics Post-translational modifications Glutamate dehydrogenase 
ProteomicsProteome-based new insights into dimethyl sulfide metabolism of Hyphomicrobium denitrificans
To get further insights in the dimethyl sulfide metabolism of Hyphomicrobium denitrificans, a LC-MS proteomic approach was used. The total protein of three biological replicates of H. denitrificans grown on dimethyl sulfide was compared with three biological replicates grown on dimethylamine. This a...
ORGANISM(S): Hyphomicrobium denitrificans ATCC 51888 
2018-06-14 | PXD009030 | Pride
Lc-msms Hyphomicrobium denitrificans Dissimilatory sulfur metabolism Dimethyl sulfide 
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsWhole genome tomato transcriptional response to Tetranychus urticae herbivory [Heinz1706]
The two-spotted spider mite, Tetranychus urticae, is one of the most significant mite pests in agriculture that can feed on more than 1,100 plant hosts, including model plants Arabidopsis thaliana and tomato, Solanum lycopersicum. Here, we described tomato transcriptional responses to spider mite fe...
ORGANISM(S): Solanum lycopersicum 
2015-01-05 | E-GEOD-61074 | biostudies-arrayexpress
TranscriptomicsWhole genome tomato transcriptional response to jasmonic acid treatment and Tetranychus urticae herbivory [def-1]
The two-spotted spider mite, Tetranychus urticae, is one of the most significant mite pests in agriculture that can feed on more than 1,100 plant hosts, including model plants Arabidopsis thaliana and tomato, Solanum lycopersicum. In order to refine the involvement of jasmonic acid (JA) in mite-indu...
ORGANISM(S): Solanum lycopersicum 
2015-01-05 | E-GEOD-61075 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human samples to compare new and stripped Affymetrix chips
new and stripped chips Experiment Overall Design: Affy1H1 = rehyb Affy1H2; Experiment Overall Design: Affy2H1 = rehyb Affy2H2
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2833 | biostudies-arrayexpress
TranscriptomicsReciprocal transcriptional responses in the interaction between Arabidopsis thaliana and Tetranychus urticae.
While pathogen-induced immunity is comparatively well characterized, far less is known about plant defense responses to arthropod herbivores. To date, most molecular-genetic studies of plant-arthropod interactions have focused on insects. However, plant-feeding (phytophagous) mites are also pests of...
ORGANISM(S): Arabidopsis thaliana 
2013-11-25 | E-GEOD-49981 | biostudies-arrayexpress
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