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TranscriptomicsMethylation Pattern of Human Dermal Fibroblasts
In this study, we have analyzed DNA methylation changes upon aging of human dermal fibroblasts by using the HumanMethylation27 BeadChip assessing 27,578 unique CpG sites. Cells were isolated from skin samples donated by young (6-23 years) and elderly (60-73 years) patients undergoing surgical interv...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-22595 | biostudies-arrayexpress
TranscriptomicsReplicative senescence of mesenchymal stem cells causes DNA methylation changes which correlate with repressive histone marks
Cells in culture undergo replicative senescence. In this study, we analyzed functional, genetic and epigenetic sequels of long‐term culture in human mesenchymal stem cells (MSC). Already within early passages the fibroblastoid colony‐ forming unit (CFU‐f) frequency and the differentiation potential ...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-26519 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for different passages of mesenchymal stem cells.
Cells in culture undergo replicative senescence and unequivocally stop proliferation after a limited number of cell divisions. In this study, we have expanded mesenchymal stem cells (MSC) from human adipose tissue and analyzed genetic and epigenetic sequels. The subpopulation of highly proliferative...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-27135 | biostudies-arrayexpress
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