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GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
GenomicsSplicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 lysine 36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here we show that splicing can also contribute to histone modification, which implies a bidirectional communication between epigenetics and RNA processing. Genome-wide analysis of histone methylation in human cell ...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30902 | biostudies-arrayexpress
GenomicsEffect of Ets1 knockdown in the P5424 thymic cell line
We performed ChIP-Seq for Ets1 and histone modifications in P5424 thymic cells, without and with Ets1 knockdown via shRNA. Overall, we find that loss of Ets1 results in specific, higher occupancy of H3K4me1-marked nucleosomes at the Ets1 binding site, but not H3K4me3 nucleosomes. We verified the spe...
ORGANISM(S): Mus musculus 
2015-12-19 | E-GEOD-74042 | biostudies-arrayexpress
GenomicsTranscriptional landscape of Rag2 -/- thymocytes [Mnase-Seq]
We performed ChIP-Seq for hallmark TFs (Ets1, Runx1), histone modification marks (H3K4me1, H3K4me2, H3K4me3, H3K27me3, H3K36me3), total RNA Pol II, short RNA-Seq as well as nucleosome mapping mainly in murine Rag2 -/- thymocytes. We also performed ChIP-Seq for E47 as well as nucleosome mapping, gene...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-56360 | biostudies-arrayexpress
GenomicsTranscriptional landscape of Rag2 -/- thymocytes [ChIP-Seq]
We performed ChIP-Seq for hallmark TFs (Ets1, Runx1), histone modification marks (H3K4me1, H3K4me2, H3K4me3, H3K27me3, H3K36me3), total RNA Pol II, short RNA-Seq as well as nucleosome mapping mainly in murine Rag2 -/- thymocytes. We also performed ChIP-Seq for E47 as well as nucleosome mapping, gene...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-56393 | biostudies-arrayexpress
GenomicsChronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature [ChIP-Seq]
We performed genome-wide DNaseI hypersensitive site in FLT3-ITD and WT patient samples. We report corresponding gene expression, promoter methylation patterns of differential DHSs as well as differentially occupied TF binding motifs using surrounding DNAseI cut profiles. We examined association patt...
ORGANISM(S): Homo sapiens 
2015-07-03 | E-GEOD-64862 | biostudies-arrayexpress
UnknownA homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness.
Not available
S-EPMC6190576 | biostudies-literature
ProteomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses [metabolomics]
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12381 | biostudies-arrayexpress
TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12379 | biostudies-arrayexpress
TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses [Luminex]
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12380 | biostudies-arrayexpress
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