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ProteomicsRegulation of stress signaling by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-24 | PXD031890 | Pride
Phospholipid Stress signaling Monounsaturated fatty acid Lc-mse Mouse fibroblasts 
ProteomicsProteomic alterations in the context of survival signaling and redox homeostasis linked to de novo fatty acid biosynthesis
Cell death programs like apoptosis, necroptosis, and ferroptosis have an oxidative component linked to lipid metabolism that impacts membrane homeostasis. Evidence for cross-talk between these programs is emerging, highlighting the need for overarching regulatory mechanisms. We investigated changes ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-04 | PXD053866 | Pride
Programmed cell death Phospholipids Monounsaturated fatty acid Redox homeostasis Mouse fibroblast Cytotoxic stress 
ProteomicsRegulation of the stress proteome by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation prevents cytotoxic stress but the mechanisms are diffuse. We investigated changes in the proteom...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-06 | PXD025396 | Pride
Autophagy Erad Phospholipid Programmed cell death Upr Stress signaling Monounsaturated fatty acid Mouse fibroblast 
UnknownRegeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response
Not available
S-SCDT-EMBOR-2021-52905V1P | biostudies-other
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