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TranscriptomicsTranscription profiling of human cancer cells treated with unfolded protein response modulators under endoplasmic reticulum stress conditions
The unfolded protein response (UPR) is a cellular defense mechanism against glucose deprivation, a cell condition that occurs in solid tumors. A key feature of the UPR is the activation of the transcription program that allows the cell to cope with endoplasmic reticulum (ER) stress. We used micoarra...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-13548 | biostudies-arrayexpress
ProteomicsUBXN1 maintains ER proteostasis and represses UPR activation by modulating translation
ER protein homeostasis (proteostasis) is essential to facilitate proper folding and maturation of proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of misfolded or aberrant proteins in the ER and triggers the unfolded protein response (UPR). Here we find that th...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043686 | Pride
Ubxn Tmt Upr Er stress Proteostasis 
ProteomicsPRM of Nt-arginylation under UPR stress
Targeted proteomics of Nt-arginylation on HeLa proteome under the stress of unfolded protein response. UPR was derived by combinational treatment of MG132 and thapsigargin. PRM method was selected to undertake targeted MS2 analysis. Data was prepared to have duplicates.
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD058872 | Pride
Human Nt-arginylation Hela Upr 
GenomicsSARS-COV2-UPR
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2
PRJEB51271 | ENA
ProteomicsTranslocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR
Translocational attenuation regulated by PERK-SRP14 axis is a novel protective mechanism of UPR
ORGANISM(S): Homo Sapiens 
PXD052453 |
TranscriptomicsUnfolded protein response in wildtype, ire1, gcn4, gcn2
We measured steady-state mRNA levels by microarray hybridization, comparing WT, (delta)ire1, (delta)gcn4, and (delta)gcn2 cells treated with 2 mM DTT for 30 min (by which time the UPR is qualitatively complete) to untreated samples of the same genotype. WT cells were taken as a positive control for ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-06 | E-GEOD-1688 | biostudies-arrayexpress
ProteomicsEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed on a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteostasis and cell function. The UPR is initiated...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD022554 | Pride
Xbp1 Huntington`s disease Atf6 Upr Parkinson`s disease Er stress Protein aggregation 
GenomicsGenome-wide CRISPR screen for ER stress-UPR pathway
Genome-wide CRISPR screen for ER stress-UPR pathway
PRJNA612074 | ENA
ProteomicsSpirocyclic dimer (SpiD7) activates unfolded protein response (UPR) to selectively inhibit growth and induce apoptosis of cancer cells
Protein homeostasis is maintained by a combination of tightly controlled processes which include synthesis, folding, trafficking and degradation. Transient accumulation of unfolded / misfolded proteins in the endoplasmic reticulum (ER) due to cell intrinsic and / or extrinsic signals results in the ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029783 | Pride
Unfolded protein response (upr) 
GenomicsPhysiological UPR induction drives gametogenesis through coordination of protein synthesis and ER structure 
Physiological UPR induction drives gametogenesis through coordination of protein synthesis and ER structure 
PRJNA1311581 | ENA
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