Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse telencephalon primary cultures from Xbp1 knockouts and wild-type controls
XBP1 is a transcription factor that is induced by unconventional splicing associated with endoplasmic reticulum stress and plays a role in development of liver and plasma cells. We previously reported that brain derived neurotrophic factor (BDNF) leads to splicing of XBP1 mRNA in neurites, and that ...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-11322 | biostudies-arrayexpress
ProteomicsFbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
In Drosophila melanogaster, Fbxo42 acts downstream of Unfolded Protein Response activation but upstream of the apoptotic machinery. Fbxo42 associates through its N-terminal F-box domain with SkpA, a component of the RBX-SCF E3 ubiquitin ligase complex. Hence, in order to uncover Fbxo42 substrates, w...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-01 | PXD065621 | Pride
Alaxin-2 Upr Fbxo42 Xbp1 
TranscriptomicsHepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet
Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expresse...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-64824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breat cancer cell lines reveals XBP1 confers estrogen independence and antiestrogen resistance
Human X-box binding protein-1 (XBP1) is an alternatively spliced transcription factor that participates in the unfolded protein response (UPR), a stress signaling pathway that allows cells to survive the accumulation of unfolded proteins in the endoplasmic reticulum lumen. We have previously demons...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8562 | biostudies-arrayexpress
GenomicsTime course Total RNA-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice
Time course Total RNA-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice
PRJNA633945 | ENA
GenomicsXbp1 binding during log phase and stationary phase.
Xbp1 binding during log phase and stationary phase.
PRJNA868333 | ENA
GenomicsTime course XBP1s ChIP-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice
Time course XBP1s ChIP-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice
PRJNA633946 | ENA
GenomicsThe role of hepatic XBP1 in FXR null mice
The role of hepatic XBP1 in FXR null mice
PRJNA833429 | ENA
GenomicsGenome-wide analysis of XBP1 binding in astrocytes during EAE
Genome-wide analysis of XBP1 binding in astrocytes during EAE
PRJNA499097 | ENA
GenomicsBulk RNAseq of control, XBP1-deficient or XBP1/IRE1-deficient cDC1s from subcutaneous B16- melanoma bearing mice
Bulk RNAseq of control, XBP1-deficient or XBP1/IRE1-deficient cDC1s from subcutaneous B16- melanoma bearing mice
PRJNA800664 | ENA
Sort   by:  
 Page size