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ProteomicsFBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Dysregulation of the Notch-RBPJ signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its interactors and modifications is still largely unknown. In this study, using a proteomic approach, we ide...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034938 | Pride
Rbpj Notch signaling Ubiquitination 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
Abstract F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma ste...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069593 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069496 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069542 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsFbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
In Drosophila melanogaster, Fbxo42 acts downstream of Unfolded Protein Response activation but upstream of the apoptotic machinery. Fbxo42 associates through its N-terminal F-box domain with SkpA, a component of the RBX-SCF E3 ubiquitin ligase complex. Hence, in order to uncover Fbxo42 substrates, w...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-01 | PXD065621 | Pride
Alaxin-2 Upr Fbxo42 Xbp1 
UnknownFBXO42 promotes hepatocellular carcinoma progression via mediating p57Kip2 ubiquitination and degradation.
Not available
S-EPMC12369267 | biostudies-literature
GenomicsFBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
PRJNA853263 | ENA
GenomicsFBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Dysregulation of the Notch-RBPJ signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its interactors and modifications is still largely unknown. In this study, using a proteomic approach, we ide...
ORGANISM(S): Homo sapiens 
2022-07-31 | GSE206985 | GEO
UnknownPervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase.
Not available
S-EPMC12909836 | biostudies-literature
UnknownGenetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.
Not available
S-EPMC3848964 | biostudies-literature
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