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MetabolomicsDifferences in metabolism in mouse embryonic fibroblasts (control vs SCF-beta-TrCP knockout)
Not available
ORGANISM(S): Mus musculus 
ST000701 | MetabolomicsWorkbench
TranscriptomicsScf-GFP+ cells from the bone marrow and whole bone marrow microarray
The HSC niche factor SCF is required for HSC maintenance. Using an Scf-GFP knockin mouse, we have identified a perivascular cell type in the bone marrow expressing high level of Scf. To characterize the novel Scf-GFP+ cells from the bone marrow, we performed microarray analysis on these cells. Total...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-33158 | biostudies-arrayexpress
ProteomicsSCF dynamics regulated by CAND2
The effect of CAND2 on SCF dynamics was studied by AP-MS.
ORGANISM(S): Homo sapiens (Human) 
2025-01-20 | PXD045618 | Pride
Scf  dynamics  cand2 
ProteomicsSCF treatment on murine DRG phospho-proteomics
We employed LC-MS/MS to determine downstream targets of the stem cell factor (SCF)/c-Kit axis in the dorsal root ganglion (DRG). Briefly, we dissected lumbar DRG from male C57BL/6 mice and treated ex vivo with vehicle or SCF for 10 min or 1 hour. DRG were then subjected to LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-28 | PXD076785 | Pride
Lc-ms/ms Pain Drg Scf 
TranscriptomicsMast cell microRNAs regulated by KIT signaling
Objective is to identify microRNAs regulated by KIT signaling in mast cells. miRNA profiles of murine bone marrow derived mast cells with and without SCF treatment were compared. In addition, miRNA profiles of the P815 mutant KIT cell line with and without the KIT inhibitor, imatinib, were compare...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26783 | biostudies-arrayexpress
ProteomicsGlobal phosphoproteomics in SCF stimulated human skin mast cells
Global phosphoproteomics can reveal signaling cascades in unprecedented detail. The SCF/KIT axis represents a vital hematopoietic receptor tyrosine kinase (RTK) system with gain-of-function mutations prompting the development of mastocytosis and leukemia. Here, we employed a label-free phosphoproteo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-31 | PXD028245 | Pride
Phosphoproteome Human Scf Mast cells 
ProteomicsSystemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cells adapt to ever-changing environmental cues by remodeling their inventories of multiprotein complexes. The cellular repertoire of modular multiprotein SCF (SKP1-CUL1-Fbox protein) E3 ligase complexes - which mediate much protein degradation - requires CAND1 to distribute the limiting CUL1 subuni...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD038661 | Pride
Crl Ligase Cand1 Scf Formation Assembly Ubiquitin Complex E3 
TranscriptomicsStem cell factor programs the mast cell activation phenotype
Mast cells, activated by antigen via the high affinity receptor for IgE (FcεRI), release an array of pro-inflammatory mediators that contribute to allergic disorders such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation and survi...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35332 | biostudies-arrayexpress
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Profiling of active cullin-RING ubiquitin E3 ligases was performed in naive or FBXO31 kno...
ORGANISM(S): Homo sapiens (Human) 
2024-11-07 | PXD055518 | Pride
Ligase Cullin Fbxo31 Ring Scf Ubiquitin E3 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 - Interaction Proteomics of FBXO31 in HEK293T cells
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Immunoprecipitation followed by MS (IP-MS) was performed on HA-tagged cDNA-expressed var...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055535 | Pride
Ap-ms Fbxo31 Ip-ms Oxidative stress Ubiquitin ligase 
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