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ProteomicsSCF treatment on murine DRG phospho-proteomics
We employed LC-MS/MS to determine downstream targets of the stem cell factor (SCF)/c-Kit axis in the dorsal root ganglion (DRG). Briefly, we dissected lumbar DRG from male C57BL/6 mice and treated ex vivo with vehicle or SCF for 10 min or 1 hour. DRG were then subjected to LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-28 | PXD076785 | Pride
Lc-ms/ms Pain Drg Scf 
TranscriptomicsTranscription profiling of mouse embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time series of neurite outgrowth in vitro
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time series of neurite outgrowth in vitro
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9740 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiling in the spinal nerve ligation model of neuropathic pain in rats
Expression profiling of L4 and L5 Dorsal Root Ganglion (DRG) in the spinal nerve ligation model of neuropathic pain. The goal of the study was to identify genes involved in neuropathic pain This series of samples comprises of contralateral and ipsilateral L4 and L5 DRG tissue collected 4 weeks afte...
ORGANISM(S): Rattus norvegicus 
2011-10-17 | E-GEOD-24982 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of FACS purified somatosensory neuron subtypes and whole dorsal root ganglia tissue
The goal of this study was to analyze global gene expression in specific populations of somatosensory neurons in the periphery, including major, non-overlapping populations that include nociceptors, pruriceptors, and prorioceptors. The mammalian somatosensory nervous system encodes the perception of...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-55114 | biostudies-arrayexpress
TranscriptomicsComparative microarray analysis of NaV1.8-expressing DRG neurons and cold-sensitive non-NaV1.8-expressing DRG neurons
The vast majority of cold sensitive DRG neurons from mice do not express the voltage-gated sodium channel NaV1.8. Therefore, we aimed to compare the molecular profiles of NaV1.8 and non-NaV1.8-expressing neurons using microarray analysis. Fluorescent activated cell sorting was performed at 4 degrees...
ORGANISM(S): Mus musculus musculus 
2019-07-01 | E-MTAB-7070 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Analyse of gene expression modification after chronic analgesic treatment. The hypothesis tested in the present study was that oxycodone and morphine induced gene expression modification. Results provide important information to understand the analgesic effects of oxycodone as compared to morphine i...
ORGANISM(S): Rattus norvegicus 
2014-01-09 | E-GEOD-53897 | biostudies-arrayexpress
GenomicsMouse DRG RNA-Seq
Mouse DRG RNA-Seq
PRJNA895420 | ENA
ProteomicsIntegrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phosphoproteomics, and metabolomics
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-09 | MSV000091027 | MassIVE
GenomicsBulk-RNA human DRG slices after plexus injury
DRG plexus injury
PRJEB71432 | ENA
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