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ProteomicsRBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1
Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. At the molecular level, the key components of the Notch pathway are the NOTCH-family receptors, the ligands of the DSL (Delta, Serrate, Lag-2) family and the transcription factor CS...
ORGANISM(S): Homo sapiens (Human) 
2017-10-17 | PXD004196 | Pride
Rbpj Notch Kdm1a L3mbtl3 
ProteomicsFBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Dysregulation of the Notch-RBPJ signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its interactors and modifications is still largely unknown. In this study, using a proteomic approach, we ide...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034938 | Pride
Rbpj Notch signaling Ubiquitination 
GenomicsSpecific mitotic chromatin association of the major notch effector RBPJ and its implication for transcriptional memory
From the cell-based investigation, RBPJ is one of the few proteins retained on chromatin during cell division. ChIP-seq experiments were performed to understand the binding pattern of RBPJ between interphase and mitosis and to identify the genes requiring RBPJ binding for the maintenance of transcri...
ORGANISM(S): Mus musculus 
2014-05-14 | E-GEOD-45889 | biostudies-arrayexpress
TranscriptomicsDynamic binding of RBPJ is determined by Notch signalling status
Notch signalling plays crucial roles in mediating cell fate choices in all metazoans largely by specifying the transcriptional output of one cell in response to a neighbouring cell. The DNA-binding protein RBPJ is the principle effector of this pathway in mammals and together with the transcription ...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-37184 | biostudies-arrayexpress
GenomicsGenome-wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T cell progenitors. Using ChIP-Seq, we find that in human and murine T-LL genomes Notch1 binds preferentially to promoters, to RBPJ binding sites, and near imputed ZNF143, Ets and Ru...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-29600 | biostudies-arrayexpress
GenomicsChIP-seq NS5 RBPJ
Here we performed a ChIP-seq experiment on a sample of adherent cultures of mouse neural stem cells (NS5 cell line) under normal growth conditions. This resulted in the generation of a genome-wide map of RBPJ binding to chromatin.
ORGANISM(S): Mus musculus 
2016-09-09 | E-MTAB-4494 | biostudies-arrayexpress
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
GenomicsRbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen Rbpj WT and Rbpj KO ATAC-seq]
Rbpj expression in regulatory T cells is critical for restraining TH2 responses [spleen Rbpj WT and Rbpj KO ATAC-seq]
PRJNA488291 | ENA
GenomicsChIP-seq NS5 RBPJ
ChIP-seq NS5 RBPJ
PRJEB12778 | ENA
GenomicsAnalysis of the genomic regions controlled by RBPJ in alveolar macrophages (RBPJ HT-ChIPmentation)
Analysis of the genomic regions controlled by RBPJ in alveolar macrophages (RBPJ HT-ChIPmentation)
PRJNA1390735 | ENA
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