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ProteomicsRBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1
Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. At the molecular level, the key components of the Notch pathway are the NOTCH-family receptors, the ligands of the DSL (Delta, Serrate, Lag-2) family and the transcription factor CS...
ORGANISM(S): Homo sapiens (Human) 
2017-10-17 | PXD004196 | Pride
Rbpj Notch Kdm1a L3mbtl3 
GenomicsMessenger RNA expression profiling in L3mbtl3 WT versus L3mbtl3 KO/+ mouse cerebella.
Messenger RNA expression profiling in L3mbtl3 WT versus L3mbtl3 KO/+ mouse cerebella.
PRJNA635879 | ENA
ProteomicsUsing L3MBTL3 knockout and rescued stable human breast cancer cell line (MDA-MB-231) to detect the novel interacting proteins of L3MBTL3 by immunoaffinity purification and mass spectrometry. Identification of L3MBTL3 interaction proteins in the breast cancer cell.
We used L3MBTL3 knockout MDA-MB-231 cell (L3-KO5+V) and L3MBTL3 rescue MDA-MB-231 cell (L3-KO5+L3). The cells were collected by centrifugation and lysed in lysis buffer (50 mM Tris-HCl, pH 7.4, 150 mM NaCl, 1 mM EDTA, 0.1% NP40, 8% glycerol, protease inhibitor cocktail (#P1010, Beyotime, China) on i...
ORGANISM(S): Homo sapiens (Human) 
2024-10-25 | PXD040150 | Pride
Human Breast cancer cell L3mbtl3 
TranscriptomicsMessenger RNA expression profiling in L3mbtl3 WT versus L3mbtl3 KO/+ mouse cerebella.
The NOTCH/RBPJ pathway governs cell proliferation in many biological contexts, including SHH and Group#3 medulloblastoma (MB) tumorigenesis. Using our proteomic platform, we discovered an interaction between RBPJ, a key co-factor of NOTCH for the modulation of the NOTCH/RBPJ signaling pathway, and L...
ORGANISM(S): Mus musculus 
2021-05-28 | GSE151448 | GEO
UnknownThe L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer.
Not available
S-EPMC4775453 | biostudies-literature
UnknownDiscovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
Not available
S-EPMC3577944 | biostudies-literature
UnknownThe structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
Not available
S-EPMC3897169 | biostudies-literature
GenomicsThe CBF1/L3MBTL3 axis promotes the repression of Notch signaling by the histone demethylase KDM1A
We performed ChIP-seq experiments to investigate on a genome-wide scale the co-localization of CBF1 (also known as RBPJ or CSL) and L3MBTL3 on chromatin in the MDA-MB-231 cell line. Analysis of the CBF1 and L3MBTL3 ChIP-seq experiments in the MDA-MB-231 cell line revealed a substantial and significa...
ORGANISM(S): Homo sapiens 
2017-10-12 | GSE100375 | GEO
UnknownL3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.
Not available
S-EPMC11696420 | biostudies-literature
GenomicsIdentification of the PRC1-interacting protein, L3mbtl3 as a novel gatekeeper of neocortical neurogenesis and proneural gene function
Identification of the PRC1-interacting protein, L3mbtl3 as a novel gatekeeper of neocortical neurogenesis and proneural gene function
PRJNA743511 | ENA
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