Sort   by:  
 Page size 
ProteomicsImmunoprecipitates of KDM1A in HepG2 cells with stably overexpressed KDM1A
KDM1A requires an adaptor protein with specific DNA-binding activity to recognize chromatin sequence. We constructed HepG2 cells stably overexpressing KDM1A-Flag tag using lentivirus. We performed Co-IP with Flag-gel and we used LC-MS to determine the immunoprecipitates of KDM1A.
ORGANISM(S): Homo Sapiens 
PXD043284 |
TranscriptomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [RNA-Seq]
Investigating the effects of two different classes of KDM1A inhibitors on the transcriptome of AML cell lines 16 different samples with biological replicates. Treatment for 24 and 72 hours with an irreversible KDM1A inhibitor (RN-1) or a reversible KDM1A inhibitor (GSK690) or an inactive isomer of ...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71740 | biostudies-arrayexpress
ProteomicsProteomic Analysis of the ubiquitination sites of KDM1A in rat myocardial tissue.
The ubiquitination sites of KDM1A in myocardial tissue were detected by Mass spectrometry.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-19 | PXD070295 | Pride
Myocardial tissue Rat Lc-ms 
GenomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [ChIP-Seq]
Examine the distribution of KDM1A and the histone H3K4me2 mark on chromatin following treatment with two distinct classes of KDM1A inhibitors - an irreversible inhibitor (RN-1) and a reversible inhibitor (GSK690) 15 samples total from two treated cell lines - 9 from Kasumi-1 and 6 from SKNO-1. Cont...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71739 | biostudies-arrayexpress
GenomicsThe histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (ChIP-Seq data)
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing di...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-36346 | biostudies-arrayexpress
GenomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
This SuperSeries is composed of the following subset Series: GSE34672: Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array] GSE34725: Inhibition of the LSD1 (KDM1A) demethylase...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34726 | biostudies-arrayexpress
ProteomicsTargeting Lysine-Specific Demethylase 1 (KDM1A/LSD1) Impairs Colorectal Cancer Tumorigenesis by Affecting Cancer Cells Stemness, Motility and Differentiation
Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading cause of death worldwide. New therapeutic strategies are required to target cancer stem cells (CSCs), a subset of tumor cells highly resistant to present-day therapy and responsible for tumor relapse. CSCs display ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037259 | Pride
Epigenome Kdm1a Tumor Proteome Crc-scs Lc-ms/ms 
GenomicsThe histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
This SuperSeries is composed of the following subset Series: GSE36346: The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (ChIP-Seq data) GSE36347: The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (expression dat...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-36348 | biostudies-arrayexpress
GenomicsThe KDM1A and KDM7A lysine demethylases cooperate to regulate androgen receptor function in prostate cancer cells [KDM1A & KDM7A inhibitors]
The KDM1A and KDM7A lysine demethylases cooperate to regulate androgen receptor function in prostate cancer cells [KDM1A & KDM7A inhibitors]
PRJNA800050 | ENA
TranscriptomicsEffects of the histone demethylase LSD1/KDM1A on the gene expression program of murine hematopoietic progenitor cells.
We established transgenic mice overexpressing the histone demethyase LSD1/KDM1A under the control of Sca-1 promoter and investigated the global changes in gene expression in hematopoietic progenitor cells using a microarray- based approach. We isolated mRNA from Sca-1-positive hematopoietic progenit...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-66074 | biostudies-arrayexpress
Sort   by:  
 Page size